AI Article Synopsis
- Sustained adrenergic overload can lead to harmful changes in the heart, characterized by oxidative stress, which can worsen heart function.
- Boldine (BOL), an antioxidant, was tested for its potential to protect the heart from damage caused by isoproterenol (ISO) in a rat study.
- Results showed that BOL significantly reduced heart enlargement and improved oxidative stress markers compared to ISO alone, suggesting it could be a beneficial treatment for adverse cardiac changes.
Article Abstract
Sustained adrenergic overload in the heart causes maladaptive cardiac remodelling, which involves oxidative stress. Boldine (BOL) has antioxidant activity and represents a novel therapeutic approach. This study explored the cardioprotective role of BOL in adverse left ventricular remodelling induced by isoproterenol. The rats were divided into four groups: control; BOL (25 mg/kg daily); isoproterenol (ISO) (5 mg/kg daily), and ISO + BOL. Morphometric, echocardiographic, and oxidative stress parameters were evaluated. BOL attenuated both cardiac hypertrophy and increased diastolic volume caused by adrenergic overstimulation (P < 0.05). BOL treatment reduced lipid peroxidation induced by ISO (ISO vs. ISO + BOL; P < 0.05), and this effect was associated with increased superoxide dismutase (SOD) (ISO vs. ISO + BOL; P < 0.05) and glutathione-S-transferase levels (GST) (ISO vs. ISO + BOL; P < 0.05). This data suggest that BOL may improve cardiac oxidative stress and attenuate some parameters of adverse cardiac remodelling.
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| http://dx.doi.org/10.1080/13813455.2024.2441363 | DOI Listing |
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