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Estimated Cancer Incidence in Northern Tunisia in 2023: Northern Tunisia Cancer Registry.
Asian Pac J Cancer Prev
December 2024
Department of Epidemiology and Biostatistics, Salah Azaiz Institute of Cancer, Tunis, Tunisia.
Background: Cancer is a major cause of morbidity and mortality in Tunisia. The objectives of our study were to estimate the incidence level of the main cancer sites in Northern Tunisia in 2023 and to dress projections till 2040.
Methods: The population based cancer registry database of northern Tunisia was the source of cases of this study.
Melanoma and worry.
J Am Acad Dermatol
December 2024
Division of Dermatology, Cooper Medical School of Rowan University, Camden, New Jersey. Electronic address:
Changes in Skin Cancer-Related Behaviors, Distress, and Beliefs in Response to Receipt of Low- to Moderate-Penetrance Genetic Test Results for Skin Cancer Risk.
Cancers (Basel)
November 2024
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33162, USA.
Little is known about the impact of low- to moderate-penetrance genetic testing for skin cancer, which is a promising approach to skin cancer prevention. To address this deficit, we conducted an analysis comparing changes in skin cancer-related behaviors, distress, and beliefs measured at a baseline and twice after the receipt of skin cancer precision prevention materials containing risk feedback (higher or average risk) among 568 non-Hispanic White (NHW) and 463 Hispanic participants. Regression analyses identified decreased average weekend hours in the sun (β = -0.
View Article and Find Full Text PDFStrongly ROS-Correlated, Time-Dependent, and Selective Antiproliferative Effects of Synthesized Nano Vesicles on BRAF Mutant Melanoma Cells and Their Hyaluronic Acid-Based Hydrogel Formulation.
Int J Mol Sci
September 2024
Department of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.
Cutaneous metastatic melanoma (CMM) is the most aggressive form of skin cancer with a poor prognosis. Drug-induced secondary tumorigenesis and the emergency of drug resistance worsen an already worrying scenario, thus rendering urgent the development of new treatments not dealing with mutable cellular processes. Triphenyl phosphonium salts (TPPSs), in addiction to acting as cytoplasmic membrane disruptors, are reported to be mitochondria-targeting compounds, exerting anticancer effects mainly by damaging their membranes and causing depolarization, impairing mitochondria functions and their DNA, triggering oxidative stress (OS), and priming primarily apoptotic cell death.
View Article and Find Full Text PDFCreating a path during melanoma amoeboid migration: When too crowded, start worrying.
Dev Cell
September 2024
Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28029 Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario La Paz (IdiPAZ), 28046 Madrid, Spain. Electronic address:
Invasion of some cancer cells into surrounding tissues requires traversing dense environments, although the precise mechanisms are unclear. In this issue of Developmental Cell, Driscoll et al. (2024) show that amoeboid melanoma cells create tunnels via bleb-driven abrasion of the extracellular matrix (ECM) without proteolytic degradation, a mechanism coined "worrying.
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