Introduction: Kidney transplantation (KT) in older age is increasingly common as more elderly patients live with end-stage renal disease. Immunosuppression (IS) after KT confers additional risk in aging patients with weakened immune systems. We hypothesized that 1-year mortality among KT recipients aged 70 y and older would be higher in those receiving induction IS with alemtuzumab lymphocyte depletion versus basiliximab interleukin-2 inhibition.
Methods: This single-institution retrospective analysis enrolled KT recipients aged 70 y and older who underwent transplantation between January 2010 and June 2022. Data were obtained from the United Network for Organ Sharing and the electronic medical record. Descriptive comparisons were performed using chi-squared, Fisher's exact, and Wilcoxon rank-sum tests as appropriate. The primary outcome was a risk-adjusted analysis to assess the association of induction IS type with 1-year mortality.
Results: The median age was 72 y [IQR 70-74] among 146 eligible KT recipients. Induction IS was achieved with alemtuzumab in 47 recipients and basiliximab in 99 recipients. At 1 y, higher rates of mortality (17.0% versus 3.0%, P = 0.005), infectious death (12.8% versus 1%, P = 0.005), and graft failure (21.3% versus 6.1%, P = 0.006) were observed among alemtuzumab compared to basiliximab recipients, with no significant difference in biopsy-proven acute rejection rate. On multivariate analysis, alemtuzumab was independently associated with 1-year mortality (P = 0.012).
Conclusions: Alemtuzumab is associated with increased 1-year mortality over basiliximab induction among KT recipients 70 y and older. Lymphocyte-depleting induction may contribute to inferior outcomes via infectious risk. Alemtuzumab induction should be approached with caution in this high-risk population.
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http://dx.doi.org/10.1016/j.jss.2024.11.006 | DOI Listing |
Chin J Traumatol
December 2024
Traumatology Unit, IRCCS Orthopedic Institute Galeazzi, Milan, 20157, Italy.
Purpose: Femur fractures are among the most common fractures treated surgically, representing a significant challenge for the orthopedic surgeon. Peri-implant femoral fractures (PIFFs) represent a rare complication of the surgical treatment. It is necessary to pay attention during osteosynthesis, evaluating not only the fracture site but the entire femoral skeletal structure, the characteristics of the fracture, the health comorbidities, and the risk of malunion and pseudarthrosis.
View Article and Find Full Text PDFObjectives: Investigate the consequences of the histological progression of metabolically associated steatohepatitis (MASH) and fibrosis on long-term survival after bariatric surgery.
Methods: From 1994 to 2021, 3028 patients at the University Hospital of Lille were prospectively included. Baseline liver biopsies were systematically performed with proposed follow-up biopsies 1 year after surgery, mainly in MASH patients.
J Surg Res
December 2024
Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Introduction: Kidney transplantation (KT) in older age is increasingly common as more elderly patients live with end-stage renal disease. Immunosuppression (IS) after KT confers additional risk in aging patients with weakened immune systems. We hypothesized that 1-year mortality among KT recipients aged 70 y and older would be higher in those receiving induction IS with alemtuzumab lymphocyte depletion versus basiliximab interleukin-2 inhibition.
View Article and Find Full Text PDFEur J Prev Cardiol
December 2024
Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aim: Due to the absence of validated bleeding risk tools in cancer patients undergoing percutaneous coronary intervention (PCI), we aimed to validate an adapted version of the Academic Research Consortium (ARC) High Bleeding Risk (HBR) criteria.
Methods: Consecutive patients with active or remission cancer undergoing PCI between 2012 and 2022 at Mount Sinai Hospital (New York, USA) were included. Patients were considered at HBR if they met at least one of the major ARC-HBR criteria, other than cancer, or two minor criteria.
Clin Transplant
December 2024
Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Background: Although surgical competency and anesthesia for liver transplantation (LT) have evolved significantly in the past decades, intraoperative cardiac arrest (ICA) is still an event that brings a poor prognosis to the recipient. We report a second-decade experience of ICA as a follow-up study of our first report at our institution.
Methods: This is a retrospective observational study of the medical records and the Liver Transplant Program database of our institution.
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