In addition to breaking down food, mastication plays regulatory roles in tissue homeostasis. During mastication, the oral mucosa is subjected to masticatory stress, and the maintenance between mucosal damage and repair is a key process. Despite rapid healing in the oral mucosa during chewing, the molecular mechanisms underlying repair remain unclear. In this study, we investigated the impact of masticatory stress on masticatory mucosal wound healing. Our data showed that reduced masticatory stress on the oral mucosa in mice fed a soft food diet resulted in decelerated hard palate mucosal wound healing and decreased numbers of Ki67-positive cells as compared with the hard food diet group. An RNA sequencing analysis revealed lower expression levels of the mechanosensitive gene in the hard palate mucosa, as well as lower levels of transforming growth factor β1 () and Tgf-β receptor 2 (), in the soft food diet group than the hard food diet group. Immunofluorescence staining, flow cytometry, and polymerase chain reaction analyses demonstrated that masticatory stress induced M2 polarization of macrophages surrounding the wound in the hard food diet group, leading to increased Tgf-β1 secretion. The specific deletion of in macrophages () attenuated masticatory stress-induced accelerated healing in mice. These findings reveal the crucial role of masticatory stress-induced expression in tissue repair, potentially influencing M2 polarization of mucosal macrophages and Tgf-β1 secretion. These findings underscore the pivotal role of physical stimulation in the immune response and tissue repair and may provide important insights into therapeutic interventions for tissue repair.
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http://dx.doi.org/10.1177/00220345241290778 | DOI Listing |
J Dent Res
December 2024
Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
J Clin Med
December 2024
Department of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland.
This review focuses on the coexistence of tinnitus and temporomandibular disorders in terms of epidemiological data, etiology, differential diagnosis, treatment, and interaction between the two disorders. PubMed, Google Scholar, and ClinicalKey digital databases were used to search for publications covering the years 2009-2024. Finally, 77 publications were used.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland.
Temporomandibular disorders (TMDs) encompass various clinical conditions associated with the temporomandibular joint (TMJ) and the masticatory muscles. TMD symptoms include pain in the orofacial region, restricted or altered mandibular movement, and sounds associated with the temporomandibular joint (TMJ). This condition adversely affects quality of life, social functioning, and daily activities, and may also contribute to widespread pain syndromes and comorbidities, including irritable bowel syndrome (IBS).
View Article and Find Full Text PDFOdontology
December 2024
Department of Endodontics, Faculty of Dentistry, Erciyes University, Turhan Baytop Street, No:1, Yenidoğan District, 38280, Talas, Kayseri, Turkey.
This study evaluates the stress distribution in mandibular molar teeth with external cervical resorption restored using various restorative and biomimetic materials through finite element analysis. A mandibular first molar was scanned to create a 3D model. 'Class 2Bp' external cervical resorption defects were simulated on the buccal aspect and restored with different materials.
View Article and Find Full Text PDFFront Cell Neurosci
November 2024
State Key Laboratory of Oral and Maxillofacial Reconstruction and Regneration, Department of General Dentistry and Emergency, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
The overactivity of the masticatory muscles (bruxism or teeth clenching) is associated with stress exposure, and often leading to consistent muscle pain. However, the neural mechanism underlining it is not fully understood. The central amygdala (CeA), which is linked to stress-induced behaviors and physical reactions, projects directly to the mesencephalic trigeminal nucleus (Vme), which is crucial for oral-motor coordination.
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