AI Article Synopsis
- Heart failure (HF) is a significant health issue globally, prompting research into simple prognostic factors like anion gap (AG) to better understand patient outcomes.
- Nine studies were analyzed in this review, revealing that non-survivors of HF had higher AG levels compared to survivors, suggesting a strong correlation between AG and mortality risk.
- The findings indicate that higher AG is linked to increased mortality in HF patients, which could facilitate risk assessment and management in clinical practice due to its straightforward measurement.
Article Abstract
Background: Heart failure (HF) is among the cardiovascular diseases with high morbidity and mortality worldwide. Due to the high burden of HF, finding easy-to-use prognostic factors has become important. Studies have investigated the correlation between anion gap (AG) and the HF prognosis. In this systematic review and meta-analysis, we aimed to evaluate the association between AG association with HF prognosis.
Methods: PubMed, Embase, Scopus, and the Web of Science were systematically searched for studies evaluating AG in HF prognosis. Standardized mean difference (SMD) and pooled hazard ratio (HR) in addition to 95% confidence intervals (CIs) were calculated using random-effect meta-analyses to compare survivors vs. non-survivors.
Results: Nine studies were included in this systematic review. In a random-effect meta-analysis comparing AG levels in those who died and survivors, non-survivors had significantly higher levels of AG (SMD 0.57, 95% CI 0.42 to 0.71, P < 0.0001, I = 46.4%). Meta-analysis of HRs for assessment of mortality revealed that high AG levels had significantly higher hazards of mortality, compared with low AG group (HR 1.64, 95% CI 1.35 to 1.99, P < 0.0001). Finally, a study investigated the association between intensive care unit (ICU) length of stay and AG in patients with HF which showed no significant association.
Conclusion: This study found that higher AG levels are associated with higher mortality in patients with HF which could be used in clinical settings and for patient management due to its ease of measurement and calculation. If confirmed in future studies, using this easy-to-measure index in clinical settings could provide useful information for clinicians in determining the risk of HF patients.
Clinical Trial Number: Not applicable.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660734 | PMC |
| http://dx.doi.org/10.1186/s12872-024-04420-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of psychodrama on mental health outcomes based on Chinese samples: A systematic review and meta-analysis of randomized controlled studies.
Glob Ment Health (Camb)
December 2024
Mental Health Education and Counseling Center, China University of Labor Relations, Beijing, China.
Background: Psychodrama (PD), supported by extensive global research, is increasingly becoming a vital method for alleviating psychological symptoms and promoting mental well-being in diverse populations across China. However, comprehensive evidence based on rigorous interventions is currently lacking.
Methods: This article systematically reviews the literature on randomized controlled experimental intervention studies of PD in the Chinese Mainland from 1982 to 2023.
How to reduce the adverse effects of weight stigma on the quality of life: a preferred reported items for systematic reviews and meta-analyses (PRISMA).
Front Psychol
December 2024
Département de psychologie, Université de Poitiers, Université François Rabelais de Tours, CNRS, Poitiers, UMR7295 Centre de recherches sur la cognition et l'apprentissage (CeRCA), Poitiers, France.
Introduction: Obesity, affecting 38% of adults globally, carries economic burdens and health risks like cardiovascular disease and diabetes. Weight-loss programs often face challenges due to stigma and poor body image, impacting individuals' quality of life. Research on interventions targeting weight stigma is lacking, emphasizing the need for comprehensive approaches addressing psychological and behavioral aspects for effective care.
View Article and Find Full Text PDFSynthesizing and assessing influenza vaccine evidence: Strengths and limitations of the recent ECDC report on the effectiveness of new and enhanced influenza vaccines. Communication on: the "European Centre for Disease Prevention and Control. Systematic review update on the efficacy, effectiveness and safety of newer and enhanced seasonal influenza vaccines for the prevention of laboratory confirmed influenza in individuals aged 18 years and over. Stockholm: ECDC; 2024".
Germs
September 2024
MD, FESPCH, Prof., General Practitioner, Röntgenstr. 2 82152 Martinsried, Germany.
High quality research is critical for evidence-based decision making in public health and fundamental to maintain progress and trust in immunization programs in Europe. In 2024 the European Centre for Disease Prevention and Control (ECDC) conducted an update of the 2020 systematic review to capture more recent evidence on of the efficacy, effectiveness of influenza vaccines in individuals aged 18 years and older in the prevention of laboratory-confirmed influenza. While this report was highly anticipated due to the strength of the protocol and processes put in place, during our assessment, we expressed two chief concerns.
View Article and Find Full Text PDFPGM3 insufficiency: a glycosylation disorder causing a notable T cell defect.
Front Immunol
December 2024
Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Background: Hypomorphic mutations in the () gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy. The exact etiology of this condition remains unclear.
View Article and Find Full Text PDFProton pump inhibitor effect on macrophage and neutrophil function: a systematic review.
Front Immunol
December 2024
College of Pharmacy, University of Houston, Houston, TX, United States.
Background: Proton pump inhibitors (PPIs) are one of the most used drugs worldwide. While generally considered safe, the usage of PPIs is associated with several adverse outcomes including acute infectious diseases. PPIs influence macrophage and neutrophil function although a systematic review has never been undertaken.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!