AI Article Synopsis
- DNA inversions in bacteria can create diversity by changing genes or parts of genes.
- Recent research by Chanin, West, and others shows that intragenic inversions allow a single gene to produce multiple protein variants through modifications in the sequence.
- This process expands protein diversity without adding extra genes to the genome, which is a surprising discovery.
Article Abstract
DNA inversions in bacteria were known to create diversity through intergenic or partial intergenic changes. Now, Chanin, West, et al. reveal intragenic inversions, enabling single genes to encode multiple protein variants via sequence recoding or truncation - an unexpected mechanism for expanding protein diversity without increasing genome size.
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| http://dx.doi.org/10.1016/j.tig.2024.12.002 | DOI Listing |
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Article Synopsis
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- Recent research by Chanin, West, and others shows that intragenic inversions allow a single gene to produce multiple protein variants through modifications in the sequence.
- This process expands protein diversity without adding extra genes to the genome, which is a surprising discovery.
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Bacterial populations that originate from a single bacterium are not strictly clonal and often contain subgroups with distinct phenotypes. Bacteria can generate heterogeneity through phase variation-a preprogrammed, reversible mechanism that alters gene expression levels across a population. One well-studied type of phase variation involves enzyme-mediated inversion of specific regions of genomic DNA.
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