AI Article Synopsis
- Paclitaxel causes peripheral neuropathy, which limits its dosage, and there aren't currently effective preventative treatments.
- Researchers tested calmangafodipir, a superoxide dismutase mimetic, on male rats to see if it could prevent this nerve damage from paclitaxel.
- The study found that while paclitaxel led to pain sensitivity and nerve damage, calmangafodipir showed protective effects, preventing both symptoms and signs of neuropathy in the rats.
Article Abstract
Paclitaxel induces peripheral neuropathy, which is considered a dose-limiting factor. However, appropriate prophylactic agents are currently unavailable. We investigated the prophylactic effects of calmangafodipir, a superoxide dismutase mimetic, on paclitaxel-induced peripheral neuropathy using a male rat model. Repeated administration of paclitaxel (6 mg/kg, intraperitoneal, once weekly for 4 weeks) resulted in mechanical allodynia in the von Frey test and axonal degeneration in the sciatic nerve. Conversely, calmangafodipir (1-10 mg/kg, intravenous, thrice weekly for 4 weeks) prevented mechanical allodynia and axonal degeneration induced by paclitaxel. These results suggest that calmangafodipir may inhibit paclitaxel-induced peripheral neuropathy.
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| http://dx.doi.org/10.1016/j.jphs.2024.11.004 | DOI Listing |
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