AI Article Synopsis
- Chemo-resistance is a major challenge in cancer therapy, and NRF1 and NRF2 are important in how cells handle oxidative stress, affecting tumor growth and drug resistance.
- The study examines how NRF2 functions differently in normal and cancer cells, supporting cancer survival while protecting healthy cells.
- It suggests that targeting the NRF signaling pathways could lead to new treatments that improve the effectiveness of chemotherapy against resistant tumors.
Article Abstract
The development of chemo-resistance remains a significant hurdle in effective cancer therapy. NRF1 and NRF2, key regulators of redox homeostasis, play crucial roles in the cellular response to oxidative stress, with implications for both tumor growth and resistance to chemotherapy. This study delves into the dualistic role of NRF2, exploring its protective functions in normal cells and its paradoxical support of tumor survival and drug resistance in cancerous cells. We investigate the interplay between the PERK/NRF signaling pathway, ER stress, autophagy, and the unfolded protein response, offering a mechanistic perspective on how these processes contribute to chemoresistance. Our findings suggest that targeting NRF signaling pathways may offer new avenues for overcoming resistance to chemotherapeutic agents, highlighting the importance of a nuanced approach to redox regulation in cancer treatment. This research provides a molecular basis for the development of NRF-targeted therapies, potentially enhancing the efficacy of existing cancer treatments and offering hope for more effective management of resistant tumors.
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| http://dx.doi.org/10.1016/j.ejphar.2024.177210 | DOI Listing |
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Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Academy of Silesia, Faculty of Medicine, Rolna 43, 40-555 Katowice, Poland; Research Institutes of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, MB R3E 0V9, Canada; Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 0V9, Canada. Electronic address:
Article Synopsis
- Chemo-resistance is a major challenge in cancer therapy, and NRF1 and NRF2 are important in how cells handle oxidative stress, affecting tumor growth and drug resistance.
- The study examines how NRF2 functions differently in normal and cancer cells, supporting cancer survival while protecting healthy cells.
- It suggests that targeting the NRF signaling pathways could lead to new treatments that improve the effectiveness of chemotherapy against resistant tumors.
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