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Macrophages make "sense" of obesity-driven acidity in the TME. | LitMetric

Macrophages make "sense" of obesity-driven acidity in the TME.

Cell Chem Biol

Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Published: December 2024

Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth..

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Source
http://dx.doi.org/10.1016/j.chembiol.2024.11.008DOI Listing

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