Health anxiety in cancer patients, assessed with the Whiteley Index.

Objective: Health anxiety (HA) is frequently observed in patients suffering from a severe disease such as cancer. This study aimed to test the psychometric properties of the Whiteley Index-7 (WI-7) measuring HA and to identify prognostic factors for heightened HA in cancer patients.

Methods: A sample of 1723 cancer patients, treated in a German rehabilitation clinic, completed the Whiteley Index-7, the Generalized Anxiety Disorder screener GAD-7, the Patient Health Questionnaire PHQ-9, the Fear of Progression questionnaire FoP-Q-12, the Concerns About Cancer Recurrence questionnaire CARQ-4, and two subscales of the EORTC QLQ-SURV100.

Results: The internal consistency of the WI-7 was good (Cronbach's α = 0.85), and the correlations between the WI-7 and other scales were as follows: 0.64 (GAD-7), 0.63 (PHQ-9), 0.75 (FoP-Q-12), 0.71 (CARQ-4), 0.66 (SURV-HD), and 0.75 (SURV-NHO). Women showed markedly higher levels of HA than men (effect size: d = 0.40), and patients aged 60 years and above reported lower levels of HA than younger patients (d = -0.32). Melanoma patients showed the highest HA mean score (M = 10.9), and patients receiving antibody therapy showed heightened levels of HA (M = 10.7). When considering age and sex, the effects of tumor type and treatment become smaller than in the univariate analyses.

Conclusion: The WI-7 is a suitable instrument for assessing HA in cancer patients. When evaluating the effects of cancer type or treatment on HA, one has to take into account the age and sex distribution. Younger patients and women deserve special attention regarding HA.