AI Article Synopsis
- - Biological sex plays a major role in how diseases like chronic kidney disease and acute kidney injury develop and respond to treatments, with hormones such as estrogen and testosterone affecting kidney functions differently for males and females.
- - Understanding and including sex as a biological factor in research is essential for improving data analysis and treatment strategies, leading to more personalized and effective healthcare for both sexes.
- - This paper aims to provide researchers with guidelines on effectively incorporating sex as a biological variable in their studies, which can enhance understanding of kidney diseases and contribute to better clinical outcomes through precision medicine.
Article Abstract
Biological sex significantly influences disease presentation, progression, and therapeutic outcomes in chronic kidney disease and acute kidney injury. Sex hormones, including estrogen and testosterone, modulate key renal functions, including renal blood flow, glomerular filtration, and electrolyte transport, thereby affecting disease trajectory in a sex-specific manner. It is critical for researchers to understand why and how to integrate sex as a biological variable in data collection, analysis, and reporting. Integrating a sex-based perspective in kidney research will lead to more personalized and efficacious treatment strategies, optimizing therapeutic interventions for each sex. If addressed properly, the incorporation of sex as a biological variable (SABV) in renal research not only enhances the mechanistic understanding of renal disease, but also paves the way for precision medicine, promising improved clinical outcomes and tailored treatment protocols for all patients. This paper is designed to serve as a guideline for researchers interested in rigorously incorporating sex as a biological variable in their studies.
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| http://dx.doi.org/10.1152/ajprenal.00136.2024 | DOI Listing |
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