The interplay between metabolic pathways and the epigenome is essential for proper cell differentiation. In this new study, Francisco Naya and colleagues find that the Dlk1-Dio3 noncoding RNA (ncRNA) locus regulates cell state by coordinating mitochondrial activity and histone modifications in muscle cells. To find out more about the people behind the work, we caught up with first author Amanda Pinheiro and corresponding author Francisco (Frank) Naya, Associate Professor at the Department of Biology, Boston University, USA.
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The Dlk1-Dio3 noncoding RNA cluster coordinately regulates mitochondrial respiration and chromatin structure to establish proper cell state for muscle differentiation.
Development
December 2024
Program in Molecular Biology, Cell Biology, and Molecular Biology, Boston University, Boston, MA 02215, USA.
The coordinate regulation of metabolism and epigenetics to establish cell state-specific gene expression patterns during lineage progression is a central aspect of cell differentiation, but the factors that regulate this elaborate interplay are not well-defined. The imprinted Dlk1-Dio3 noncoding RNA (ncRNA) cluster has been associated with metabolism in various progenitor cells, suggesting it functions as a regulator of metabolism and cell state. Here, we directly demonstrate that the Dlk1-Dio3 ncRNA cluster coordinates mitochondrial respiration and chromatin structure to maintain proper cell state.
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View Article and Find Full Text PDFThe Key Lnc (RNA)s in Cardiac and Skeletal Muscle Development, Regeneration, and Disease.
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Non-coding RNAs (ncRNAs) play a key role in the regulation of transcriptional and epigenetic activity in mammalian cells. Comprehensive analysis of these ncRNAs has revealed sophisticated gene regulatory mechanisms which finely tune the proper gene output required for cellular homeostasis, proliferation, and differentiation. However, this elaborate circuitry has also made it vulnerable to perturbations that often result in disease.
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