Failed replication attempts have raised concerns over the prevalence of publication bias and false positive results in the psychological literature. Using a sample of 65,970 test statistics from and , this article assesses the credibility of results in emotional research. All test statistics were converted to -scores and analysed with -curve. A -curve analysis provides information about the amount of selection bias, the expected replication rate and the false positive risk. Lastly, -curve is used to determine an alpha level that lessens the false positive risk without unnecessary loss of power. The results show evidence of selection bias in emotional research, but trend analyses showed a decrease over time. Based on the -curve estimates, we predict a 15% and 70% success rate in replication studies. Therefore, replication studies should increase sample sizes to avoid type-II errors. The risk of false positives with the traditional alpha level of 5% is between 5% and 33%. Lowering alpha to 1% is sufficient to reduce the false positive risk to less than 5%. In sum, our findings may alleviate concerns about high false positive rates among emotional researchers. However, selection bias and low power remain challenges to be addressed.
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http://dx.doi.org/10.1080/02699931.2024.2443016 | DOI Listing |
Ultrasound Obstet Gynecol
January 2025
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Objectives: To compare the maternal hemodynamic profile at 12 + 0 to 15 + 6 weeks' gestation in women who subsequently developed pre-eclampsia (PE) and those who did not, and to assess the screening performance of maternal hemodynamic parameters for PE in combination with the Fetal Medicine Foundation (FMF) triple test, including maternal factors (MF), mean arterial pressure (MAP), uterine artery pulsatility index and placental growth factor.
Methods: This was a prospective case-control study involving Chinese women with a singleton pregnancy who underwent preterm PE screening at 11 + 0 to 13 + 6 weeks' gestation using the FMF triple test, between February 2020 and February 2023. Women identified as being at high risk (≥ 1:100) for preterm PE by the FMF triple test were matched 1:1 with women identified as low risk (< 1:100) for maternal age ± 3 years, maternal weight ± 5 kg and date of screening ± 14 days.
NPJ Syst Biol Appl
January 2025
Department of Bioscience & Bioengineering, Indian Institute of Technology, Jodhpur, Rajasthan, India.
Classification of adenocarcinoma (AC) and squamous cell carcinoma (SCC) poses significant challenges for cytopathologists, often necessitating clinical tests and biopsies that delay treatment initiation. To address this, we developed a machine learning-based approach utilizing resected lung-tissue microbiome of AC and SCC patients for subtype classification. Differentially enriched taxa were identified using LEfSe, revealing ten potential microbial markers.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Comparative glycomics data are compositional data, where measured glycans are parts of a whole, indicated by relative abundances. Applying traditional statistical analyses to these data often results in misleading conclusions, such as spurious "decreases" of glycans when other structures increase in abundance, or high false-positive rates for differential abundance. Our work introduces a compositional data analysis framework, tailored to comparative glycomics, to account for these data dependencies.
View Article and Find Full Text PDFRadiography (Lond)
January 2025
Discipline of Medical Imaging Science, University of Sydney, Camperdown, NSW, Australia. Electronic address:
Introduction: Radiography and medical students (RMS), upon graduation, require capabilities to provide life-saving care through identification and communication of urgent findings on radiological imaging. This preliminary study investigated RMS' ability to identify and categorise urgent findings on CT examinations. It also explored their experiences of image interpretation education.
View Article and Find Full Text PDFMethods Cell Biol
January 2025
Laboratorio de Inmunologia y Virologia, Facultad de Ciencias Biologicas, Universidad Autónoma de Nuevo Leon, San Nicolás de los Garza, Nuevo León, Mexico. Electronic address:
Cancer immunotherapy has revolutionized cancer treatment by harnessing the immune system's potential to combat cancer. Among the various strategies in this field, the use of killed tumor cells (KC) induced by immunogenic cell death (ICD) inducers has gained attraction. This approach involves the treatment of cancer cells in vitro, followed by the subcutaneous injection of these killed cells into tumor-bearing mice.
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