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Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4/FoxO3a pathway.
Cell Signal
December 2024
Department of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin 300070, China. Electronic address:
This study aimed to investigate the underlying mechanisms by which physical exercise mitigates muscle atrophy induced by Dexamethasone (Dex). A muscle atrophy model was established in the mouse C2C12 cell line and 8-week-old mice treated with Dex, with subsequent verification of phenotype and atrogene expression. The potential benefits of combined aerobic and resistance exercise in mitigating muscle atrophy were then examined.
View Article and Find Full Text PDFImpacts of Depressive Symptoms on the Effectiveness of a Theory-Driven Exercise Intervention Among Community-Dwelling (Pre)frail Older Adults.
Clin Gerontol
December 2024
School of Nursing, Peking University, Beijing, China.
Objectives: To investigate whether baseline depressive symptoms impacted the effectiveness of an exercise intervention among (pre)frail older adults.
Methods: This is a subanalysis of a stepped-wedge cluster randomized trial implementing an exercise intervention, with an application of the integration of the Health Belief Model, Theory of Planned Behavior, and Health Action Process Approach, among 149 community-dwelling (pre)frail older adults. The intervention effectiveness was examined by baseline depressive symptoms (depressive symptoms ( = 40) and non-depressive symptoms ( = 109).
[Activation of endogenous mechanisms of sanogenesis in cognitive impairment in cerebral small vessel disease].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Kazan (Volga region) Federal University, Kazan, Russia.
Cerebrovascular diseases themselves are the second most common cause of cognitive impairment (dementia). In addition, cerebral small vessel disease (CSVD) makes a significant contribution to the clinical picture of neurodegenerative diseases. Since there are currently no pharmacological treatments for CSVD, a promising method is the activation of the endogenous mechanisms of sanogenesis.
View Article and Find Full Text PDFContext: Student-run health clinics (SRHC) are commonly utilized to provide clinical experiences to students in healthcare education programs as well as healthcare services to a target community. Recent reports on athletic training SRHCs (AT-SRHCs) with a client population of university students, employees and/or community members have reported positive patient outcomes and high patient satisfaction, however there is limited data about the treated conditions, services and value provided by AT-SRHC.
Objective: To track utilization of athletic training services at a free AT-SRHC.
Association between fundamental movement skills and accelerometer-measured physical activity in orphan children with severe intellectual disabilities.
BMC Pediatr
December 2024
School of Physical Education, Shanghai University of Sport, 399 Changhai Road, Shanghai, 200438, P. R. China.
Background: Children with intellectual disabilities (ID) typically exhibit low levels of physical activity (PA) and delayed motor skills. Understanding the motor skill factors that influence PA participation in this population is essential for designing effective interventions. The purpose of this study was to examine the association between fundamental motor skills (FMS) and objectively measured PA among orphan children with severe ID residing in welfare institutions.
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