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CYP19 and ESR2 polymorphisms as potential culprits in cryptorchidism.
J Pediatr Urol
December 2024
Muğla Sıtkı Koçman University, Faculty of Medicine, Department of Pediatric Surgery, Muğla, Turkey.
Introduction: Cryptorchidism impairs sperm development and increases the risk of infertility and testicular cancer. Estrogen signalling is critical for proper descent of the testicles, and hormonal imbalances play a role in cryptorchidism. CYP19, also known as aromatase, encodes an enzyme that converts testosterone, a male sex hormone, into estradiol, the main form of estrogen.
View Article and Find Full Text PDFTMC7 is required for spermiogenesis and male fertility by regulating TGN-derived vesicles.
Int J Biol Macromol
December 2024
State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China. Electronic address:
Infertility affects 10-12 % of couples worldwide, 50 % of which are male. Abnormal spermatogenesis is among the main causes of male infertility. We were curious about the possible role of transmembrane channel-like protein 7 (TMC7) in spermatogenesis because of its aberrant expression in several male infertility patients.
View Article and Find Full Text PDFThe assessment of oxidative stress in human semen: chaos and confusion in pursuit of diagnostic precision.
Reprod Biomed Online
October 2024
CellOxess Biotechnology, Research and Development, Ewing, NJ, USA.
The importance of oxidative stress in the aetiology of male infertility has occasioned numerous clinical trials designed to assess the potential of antioxidants for treating this condition. These trials have not returned definitive results, probably because they have never selected participants on the basis of oxidative stress. Clearly, if a moderate to severe state of oxidative stress does not exist in semen, antioxidants can hardly be expected to improve fertility.
View Article and Find Full Text PDFKoala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.
Sci Rep
December 2024
Sydney School of Veterinary Science, University of Sydney, Camperdown, NSW, 2006, Australia.
Chlamydiosis is a common infectious disease impacting koalas and is a major cause of population decline due to resulting mortality and infertility. Polymorphisms of major histocompatibility complex (MHC) genes influence chlamydial disease outcomes in several species but koala studies have produced variable results. We aimed to identify the MHC II DAB and DBB repertoire of koalas from Liverpool Plains, NSW, a population heavily impacted by chlamydiosis.
View Article and Find Full Text PDFIntratesticular creatine maintains spermatogenesis by defining tight junctions.
Sci Rep
December 2024
Department of Urology, Osaka University Graduate School of Medicine, Suita, 565-0871, Osaka, Japan.
One in five couples who wish to conceive is infertile, and half of these couples have male infertility. However, the causes of male infertility are still largely unknown. Creatine is stored in the body as an energy buffer, and the testes are its second-largest reservoir after muscles.
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