AI Article Synopsis
- A 67-year-old male presented with skin plaques and bruising on the neck and hands for 2 years, along with nail issues.
- Histopathological tests indicated the presence of keratinous cysts and eosinophilic material, which tested positive for Congo red staining.
- A bone marrow biopsy confirmed multiple myeloma, leading to a diagnosis of primary systemic amyloidosis alongside multiple myeloma.
Article Abstract
A 67-year-old male presented with plaques around the orbit and ecchymosis on the neck and back of hands for 2 years. Physical examination showed seborrheic-keratosis-like plaques around the orbit, ecchymosis on the neck and back of hands, as well as nail dystrophy. Serum λ light chain was positive. Histopathological examination demonstrated multiple keratinous cysts in the dermis and eosinophilic homogeneous material in the dermis, which was positive for Congo red with apple-green birefringence on polarized light. Kidney biopsy showed deposition of acellular eosinophilic material in the arteriole wall. Congo red staining was positive. A bone marrow biopsy revealed multiple myeloma. The diagnosis of primary systemic amyloidosis with multiple myeloma was made.
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| http://dx.doi.org/10.1111/cup.14763 | DOI Listing |
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