AI Article Synopsis
- Sickle cell retinopathy (SCR) is a serious eye condition linked to sickle cell disease (SCD) that can severely affect vision, prompting recommendations for screening.
- A scoping review analyzed 67 studies to identify demographic, genetic, and hematological risk factors for SCR and sickle cell maculopathy (SCM), highlighting key risks such as older age, male sex, and specific genotypes.
- While screening is essential, further research is necessary to understand the effectiveness of treatments for SCR and the long-term impacts of SCM on patients.
Article Abstract
Sickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM). A literature search (in Medline(Ovid), Embase(Ovid) and Scopus) resulted in 67 included articles, which covered demographic risk factors, genetic risk factors, systemic therapy, correlations with other forms of SCD-related organ damage and hematological risk factors. SCR risk factors include older age, male sex, HbSC genotype, hemolysis and HbF% 15%) patients to ensure comprehensive yet proportionate ophthalmic care. However, to elucidate the sense and nonsense of screening, future studies are needed on the role of interventions for SCR and the long-term consequences of SCM.
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| http://dx.doi.org/10.3324/haematol.2024.286420 | DOI Listing |
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