AI Article Synopsis
- Pancreatic carcinoma is a highly aggressive cancer, and novel nanotechnology techniques are being explored for less invasive treatment options.
- A specialized nanoplatform called HA/DOX-AuNRs combines hyaluronic acid and doxorubicin-loaded gold nanorings, designed to enhance targeted treatment while minimizing side effects through advanced imaging and localized heating.
- Studies demonstrate that HA/DOX-AuNRs not only show effective therapeutic outcomes in lab models but also improve the overall treatment efficacy by utilizing dual-responsive mechanisms and guided imaging.
Article Abstract
Introduction: Pancreatic carcinoma (PC) is a highly malignant digestive tumor. Nanotechnology-based minimally invasive techniques have been proposed to provide a new opportunity for PC treatment.
Methods: A minimally invasive nanoplatform (named HA/DOX-AuNRs) is fabricated by HA modifying and DOX loading Au nanorings (AuNR). Because of their complicated geometric structure and tunable localized surface plasmon resonance peak in the second near-infrared laser window (NIR-II window), HA/DOX-AuNRs exhibit fluorescence/photoacoustic and photothermal properties, dual-responsive DOX release, and tumor-targeting ability. HA/DOX-AuNRs are expected to improve the tumor therapeutic efficiency and reduce undesirable side effects through fluorescence/photoacoustic dual-imaging guided targeted synergetic photothermal chemotherapy under NIR-II irradiation.
Results: The morphological and physicochemical properties of HA/DOX-AuNRs are well-examined at first. The cytotoxicity, cellular uptake, and in vitro therapeutic effect of fluorescence/photoacoustic dual-imaging guided targeted synergetic photothermal chemotherapy are evaluated in Panc-1 cells. The in vivo biodistribution, anticancer effects, and systemic toxicity are investigated using PC xenograft models.
Discussion: HA/DOX-AuNRs significantly improve the therapeutic efficacy in a dual-responsive and dual-imaging guided targeted synergy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656332 | PMC |
| http://dx.doi.org/10.2147/IJN.S476936 | DOI Listing |
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