Background The escalating global prevalence of obesity raises concerns about its implications for health outcomes. While obesity is acknowledged as a major risk factor for various diseases, its impact on appendicitis and appendectomy outcomes remains less explored. Methods Data on overweight and obese adults aged 18 to 65 treated for appendicitis in King Abdulaziz Medical City in Riyadh, Saudi Arabia were collected retrospectively. The sample included 1,471 patients who underwent laparoscopic appendectomy between January 2015 and January 2022. The sample did not include patients who were outside the age range, underwent conservative or elective treatment, or were pregnant. Data were collected via the National Guard Health Affairs (NGHA's) BESTCare 2.0 system. Statistical analyses were performed using the Statistical Analysis System (SAS) (SAS Institute Inc., Cary, NC) software. Results The final cohort comprised 564 patients, predominantly male (63.65%) with a mean body mass index (BMI) of 27.41. Comorbidities exhibited varying prevalence among BMI groups, with significant differences observed for diabetes, hyperlipidemia, and hypertension. Notably, 86.35% of the patients did not present with complicated appendicitis or encounter complications, irrespective of BMI. The study found comparable rates of diagnostic CT scan usage across BMI categories. Obese patients displayed a statistically significant trend of longer hospital stays, potentially linked to increased comorbidities and being diagnosed at a later age. Conclusion While obesity has been linked to adverse health outcomes, this study found that appendicitis and its surgical management were less influenced by obesity than previously thought. The findings advocate a nuanced approach, acknowledging the impact of obesity on hospitalization trends. This study challenges the assumption that the management of appendicitis in the obese population needs a more tailored intervention.
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http://dx.doi.org/10.7759/cureus.74033 | DOI Listing |
Age Ageing
November 2024
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Mol Biol (Mosk)
December 2024
Pirogov All-Russia National Research Medical University, Moscow, 117997 Russia.
Obesity is associated with changes in the gut microbiota, as well as with increased permeability of the intestinal wall. In 130 non-obese volunteers, 57 patients with metabolically healthy obesity (MHO), and 76 patients with metabolically unhealthy obesity (MUHO), bacterial DNA was isolated from stool samples, and the 16S rRNA gene was sequenced. The metabolic profile of the microbiota predicted by PICRUSt2 (https://huttenhower.
View Article and Find Full Text PDFMed Sci Monit
December 2024
Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, Lublin, Poland.
Polycystic ovary syndrome (PCOS) is associated with several mild metabolic disorders, including insulin resistance (IR), obesity, and dyslipidemia, as well as with some more severe ones, including type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. Clinically, mild metabolic complications of PCOS such as IR or lipid metabolism disorders are the predictors of these more severe ones. So far, there is no reliable single marker that enables defining metabolic risk in patients with PCOS.
View Article and Find Full Text PDFCardiovasc Diabetol
December 2024
Department of Cardiology, The Second Affiliate Hospital of Xi'an Jiaotong University, No.157, Xiwu Road, Xincheng District, Xi'an, 710004, Shaanxi, China.
Atrial fibrillation (AF) is the most prevalent arrhythmia in clinical practice, and obesity serves as a significant risk factor for its development. The underlying mechanisms of obesity-related AF remain intricate and have yet to be fully elucidated. We have identified FPR2 as a potential hub gene involved in obesity-related AF through comprehensive analysis of four transcriptome datasets from AF patients and one transcriptome dataset from obese individuals, and its expression is up-regulated in both AF and obese individuals.
View Article and Find Full Text PDFOrphanet J Rare Dis
December 2024
HHT Unit. Hospital Universitari Bellvitge, C/Feixa Llarga S/N. L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Background: Hereditary hemorrhagic telangiectasia (HHT) is characterized by telangiectasia and larger vascular malformations. Liver malformations are the most frequent visceral involvement including the presence of portosystemic malformations (PSM) that can cause hepatic encephalopathy. Minimal hepatic encephalopathy (mHE) is characterized by alterations of brain function in neuropsychological or neurophysiological tests and decreases quality of life.
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