Aortic coarctation represents up to 7% of congenital heart diseases and is associated with hypertension and coronary artery disease, which continues to be the leading cause of death even after successful surgical repair. However, there is limited knowledge of managing both conditions, especially in the setting of an acute coronary syndrome. We herein present the case of a 53-year-old man with a history of hypertension who initially presented with an ST-elevation myocardial infarction successfully treated with thrombolysis and hemodynamic compromise. During angioplasty, an incidental finding of aortic coarctation was noted. After a thorough evaluation by the heart team, it was determined that percutaneous revascularization with ventricular support was necessary due to the high surgical risk. Aortic coarctation repair was performed first, followed by successful angioplasty with the placement of an Impella CP device through the newly implanted aortic stent. To our knowledge, this is the first reported case of a patient with both STEMI and aortic coarctation treated sequentially and using only a percutaneous approach. It is also the first reported case where a ventricular assist device (VAD) was used to support high-risk PCI in a patient with a repaired aortic coarctation.
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Comput Biol Med
December 2024
Department of Electrical, Computer and Biomedical Engineering, Toronto Metropolitan University, 350 Victoria Street, Toronto, M5B 2K3, Canada. Electronic address:
Background: Physics-informed neural networks (PINNs) are increasingly being used to model cardiovascular blood flow. The accuracy of PINNs is dependent on flow complexity and could deteriorate in the presence of highly-dynamical blood flow conditions, but the extent of this relationship is currently unknown. Therefore, we investigated the accuracy and performance of PINNs under a range of blood flow conditions, from laminar to turbulent-like flows.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
December 2024
Interventional Cardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Aortic coarctation represents up to 7% of congenital heart diseases and is associated with hypertension and coronary artery disease, which continues to be the leading cause of death even after successful surgical repair. However, there is limited knowledge of managing both conditions, especially in the setting of an acute coronary syndrome. We herein present the case of a 53-year-old man with a history of hypertension who initially presented with an ST-elevation myocardial infarction successfully treated with thrombolysis and hemodynamic compromise.
View Article and Find Full Text PDFInt J Surg Case Rep
December 2024
The Internist Cardiologist, Department of Cardiology, Al Watani Hospital, Hama, Syria.
Introduction And Clinical Importance: Shone complex (SC) is a rare multilevel congenital heart disease (CHD) characterized by four left-sided heart obstructive lesions: parachute mitral valve, supravalvular mitral ring, subaortic stenosis, and coarctation of the aorta (CoA), accounting for 0.6-0.7 % of CHD cases.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California, United States of America.
Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. If left untreated, by the time individuals reach 50 years of age, the mortality rate can reach 90%. Previous studies have highlighted the adverse effects of CoA on local hemodynamics.
View Article and Find Full Text PDFCardiol Young
December 2024
Department of Pediatrics, Division of Pediatric Cardiology, UT Southwestern Medical Center, Dallas, TX, USA.
Background: Aortic arch obstruction and/or coarctation of aorta is uncommon (5-20%) in balanced atrioventricular septal defects. Although technically challenging, prenatal diagnosis of aortic arch obstruction in atrioventricular septal defect is critical for delivery planning and improves prenatal counselling regarding the timing of cardiac surgery. We sought to identify prenatal predictors of coarctation of aorta in atrioventricular septal defect.
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