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Combination of ATRAP deletion and angiotensin II accelerates DKD progression, which may also accelerate DKD research.
Hypertens Res
December 2024
Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Angiotensin II type 1 receptor-associated protein deletion combined with angiotensin II stimulation accelerates the development of diabetic kidney disease in mice on a C57BL/6 strain.
Hypertens Res
January 2024
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
The progress in the research field of diabetic kidney disease (DKD) has been disturbed by the lack of reliable animal models. Angiotensin II (Ang II) type 1 receptor (AT1R)-associated protein (ATRAP) promotes internalization of AT1R and selectively inhibits pathological AT1R signaling. In this study, we investigated whether overactivation of the renin-angiotensin system (RAS) through a combination of ATRAP deletion with Ang II stimulation developed a progressive DKD model in C57BL/6 mice, which are resistant to the development of kidney injury.
View Article and Find Full Text PDFThe mechanisms behind decreased internalization of angiotensin II type 1 receptor.
Vascul Pharmacol
April 2018
Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China; Beijing Key Laboratory of Cardiovascular Diseases and Related Metabolic Dysfunction, Capital Medical University, Beijing, China. Electronic address:
The internalization of angiotensin II type 1 receptor (ATR) plays an important role in maintaining cardiovascular homeostasis. Decreased receptor internalization is closely related to cardiovascular diseases induced by the abnormal activation of ATR, such as hypertension. However, the mechanism behind reduced ATR internalization is not fully understood.
View Article and Find Full Text PDFPrehypertensive preconditioning improves adult antihypertensive and cardioprotective treatment.
J Pharmacol Exp Ther
March 2010
Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany.
Transient prehypertensive treatment (TPT) causes prolonged antihypertensive and cardioprotective effects. Reduced angiotensin sensitivity has been attributed to those effects. We hypothesize that prehypertensive preconditioning by angiotensin II type 1 receptor (AT1R) blockade improves cardiovascular protection of late-onset AT1R blockade in a model of spontaneous hypertensive heart-failure rats (SHHF/Mcc-fa(cp)).
View Article and Find Full Text PDFRET: a poly A-trap retrovirus vector for reversible disruption and expression monitoring of genes in living cells.
Nucleic Acids Res
December 1999
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, MA 02115, USA.
Gene trapping is a form of insertional mutagenesis that causes disruption of gene function. Here we report the construction and extensive examination of a versatile retrovirus vector, RET (removable exon trap). The RET vector uses an improved poly A-trap strategy for the efficient identification of functional genes regardless of their expression status in target cells.
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