AI Article Synopsis

  • Metabolic syndrome (MetS) increases the risk of serious health issues like heart disease and diabetes, and while there's no cure, lifestyle changes can help manage it.
  • Sulforaphane (SFN), found in cruciferous vegetables, shows promise in treating MetS and its related conditions due to its ability to regulate fatty acid and glucose levels.
  • A review of 86 studies indicates that SFN may have beneficial effects on metabolic disorders, but more human studies are needed to confirm its effectiveness as a treatment for metabolic syndrome.

Article Abstract

The disorder known as metabolic syndrome (MetS) represents a substantial threat to society since it is linked to a higher risk of heart disease, diabetes, stroke, and other health issues. Although there is no known cure for metabolic syndrome, lifestyle changes in diet and physical activity can help. Sulforaphane (SFN), a compound in cruciferous vegetables, has been recognized as a promising treatment for addressing metabolic syndrome. The information was compiled after a thorough search of four databases, PubMed, Scopus, Web of Sciences, and Google Scholar. This analysis includes 86 studies that include clinical and nonclinical SFN investigations in diseases connected to metabolic syndrome. Research has shown that sulforaphane is a prospective treatment option for obesity, type 2 diabetes mellitus (T2-DM), and associated metabolic disorders due to its capacity to regulate fatty acid production and glucose management. Many molecular processes have been investigated, including activating nuclear factor erythroid 2-related factor 2(Nrf2), activating nuclear factor erythroid 2(NF-E2), reducing reactive oxygen species, and upregulating insulin receptor substrate 1(IRS-1) and other suggested mechanisms. The current review established many facts in favor of SFN's prospective benefits in metabolic syndrome. More studies in this field involving human studies are necessary to determine whether SFN may effectively treat metabolic syndrome.

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http://dx.doi.org/10.1007/s00210-024-03706-3DOI Listing

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