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The use of sequential multiple assignment randomized trials (SMARTs) in physical activity interventions: a systematic review. | LitMetric

The use of sequential multiple assignment randomized trials (SMARTs) in physical activity interventions: a systematic review.

BMC Med Res Methodol

School of Allied Health, Ageing Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.

Published: December 2024

AI Article Synopsis

Article Abstract

Background: Physical activity (PA) is often the cornerstone in risk-reduction interventions for the prevention and treatment of many chronic health conditions. PA interventions are inherently multi-dimensional and complex in nature. Thus, study designs used in the evaluation of PA interventions must be adaptive to intervention components and individual capacities. A Sequential Multiple Assignment Randomised Trial (SMART) is a factorial design in a sequential setting used to build effective adaptive interventions. SMARTs represent a relatively new design for PA intervention research. This systematic review aims to examine the state-of-the-art of SMARTs used to develop PA interventions, with a focus on study characteristics, design, and analyses.

Methods: PubMed, Embase, PsychINFO, CENTRAL, and CinAHL were systematically searched through May 2023 for studies wherein PA SMARTs were conducted. Methodological quality was assessed using the Cochrane Risk of Bias 2 Tool.

Results: Twenty studies across a variety of populations - e.g., obesity, chronic pain, and cardiovascular conditions, were included. All PA SMARTs involved two decision stages, with the majority including two initial treatment options. PA interventions most commonly consisted of individual aerobic exercise with strategies such as goal setting, wearable technology, and motivational interviewing also used to promote PA. Variation was observed across tailoring variables and timing of tailoring variables. Non-response strategies primarily involved augmenting and switching treatment options, and for responders to continue with initial treatment options. For analyses, most sample size estimations and outcome analyses accounted for the SMART aims specified. Techniques such as linear mixed models, weighted regressions, and Q-learning regression were frequently used. Risk of bias was high across the majority of included studies.

Conclusions: Individual-based aerobic exercise interventions supported by behaviour change techniques and wearable sensing technology may play a key role in the future development of SMARTs addressing PA intervention development. Clearer rationale for the selection of tailoring variables, timing of tailoring variables, and included measures is essential to advance PA SMART designs. Collaborative efforts from researchers, clinicians, and patients are needed in order to bridge the gap between adaptive research designs and personalised treatment pathways observed in clinical practice.

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Source
http://dx.doi.org/10.1186/s12874-024-02439-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658464PMC

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