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Red emitting fluorescence sensor based on Eu-tungstate complex for the detection of bilirubin in biological fluid. | LitMetric
Bilirubin is an important biomarker indicative of human health metabolism, especially in jaundice disease. In this work, we develop an Eu (Europium)-tungstate complex-based turn-off luminescence detection method for bilirubin in human (urineand serum)samples. The Eu-tungstate complex was synthesized by a straightforward one-pot procedure at ambient temperature, utilizing Europium chloride and Sodium tungstate as the precursors. The Eu-tungstate complex exhibited a very strong red emission and demonstrated excellent stability. The fluorescence of the Eu-tungstate complex in aqueous mediacan be turned off regularly by the gradual addition of bilirubin with a limit of detection (LoD) of 0.27 μM and alimit of quantitative (LoQ) of 0.91 μM.Moreover, this sensing technology can be utilized to sense bilirubin in actual samples.
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