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Deep ultraviolet Raman spectroscopic analysis of antihistamine drugs in oral fluid for forensic purposes. | LitMetric

Deep ultraviolet Raman spectroscopic analysis of antihistamine drugs in oral fluid for forensic purposes.

Spectrochim Acta A Mol Biomol Spectrosc

Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA. Electronic address:

Published: December 2024

AI Article Synopsis

  • - Raman spectroscopy is a non-invasive and straightforward technique that's becoming valuable in forensic analysis, especially for detecting substances in oral fluid.
  • - This study focuses on deep ultraviolet Raman spectroscopy (DUVRS) to identify the antihistamine cetirizine in both liquid and solid oral fluid samples, achieving a detection limit of 50 µg/mL.
  • - Combining DUVRS with multivariate statistical analysis allows for effective differentiation between clean oral fluid stains and those mixed with cetirizine, highlighting the need for further studies with larger sample sizes and various drug types to improve this method's forensic utility.

Article Abstract

Owing to its inherent nondestructive nature, rapid analysis and simplicity, Raman spectroscopy has emerged as a promising tool for forensic analysis of different bodily fluids, particularly oral fluid (OF). Accurate drug identification and quantification are essential for understanding the circumstances surrounding a case, such as whether it involves an overdose fatality, substance abuse, or drug trafficking. This study aims to evaluate the potential of using deep ultraviolet Raman spectroscopy (DUVRS) to detect the antihistamine cetirizine (CTZ) in liquid and solid OF samples. The application of DUVRS facilitated CTZ detection in liquid OF samples with a limit of detection (LOD) of 50 µg/mL. Additionally, integrating multivariate statistical analysis with DUVRS enabled reliable differentiation between pure OF stains and those contaminated with CTZ, thereby demonstrating its high sensitivity for CTZ detection. Further method development is warranted, involving larger cohorts of donors, increased numbers of samples, and a broader range of drug types, to enhance the practicality of this approach for forensic applications.

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Source
http://dx.doi.org/10.1016/j.saa.2024.125595DOI Listing

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