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Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis.
Sci China Life Sci
December 2024
State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling. However, the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing result. Here, we developed a rapid and robust saliva proteome profiling workflow, obtaining coverage of >1,200 proteins from a 50-µL unstimulated salivary flow with 30 min gradients.
View Article and Find Full Text PDFBackground Sickle cell disease (SCD) is a hereditary disorder marked by abnormal hemoglobin (HbS), leading to chronic hemolytic anemia, vaso-occlusive crises (VOCs), and multi-organ complications. In India, the prevalence of SCD is highest among tribal populations in states like Madhya Pradesh, Maharashtra, Odisha, and Assam, with the disease burden exacerbated by limited healthcare access, especially in rural regions. This study provides a comprehensive analysis of the demographic profile, clinical features, and treatment patterns of SCD patients at a tertiary healthcare center in Upper Assam, where the prevalence of SCD is high among the tea tribe communities.
View Article and Find Full Text PDFFeed additives for methane mitigation: Regulatory frameworks and scientific evidence requirements for the authorization of feed additives to mitigate ruminant methane emissions.
J Dairy Sci
January 2025
Estación Experimental del Zaidín, CSIC, 18008 Granada, Spain.
This article describes the regulatory and evidence requirements necessary for the authorization of antimethanogenic feed additives (AMFA) aimed at mitigating enteric methane (CH) emissions from ruminants. It outlines the legislation and legal procedures in Australia, Canada, the European Union, New Zealand, South Korea, the United Kingdom, and the United States as illustrative examples, offering insights for applicants seeking authorization. Additionals objectives are to highlight consequential similarities and differences in regulations and evidence requirements and offer recommendations for scientists and applicants.
View Article and Find Full Text PDF[Analysis of risk factors for allergic rhinitis in preschool children with multiple allergic diseases in Guangzhou City].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease,Guangzhou510120, China.
This study aims to analyze the differentiating factors between only allergic rhinitis and allergic rhinitis combined with other allergic diseases in pre-school children and to explore the impact of relevant family and maternal factors during pregnancy on pediatric allergic diseases.The study employed an epidemiological cross-sectional survey design, conducted from January to June 2022 at the Helong Street Health Service Center in Baiyun District, Guangzhou City, China. This cross-sectional investigation focused on 15 preschool education centers within the jurisdiction.
View Article and Find Full Text PDFModularity buffers the spread of spatial perturbations in macroalgal networks.
Curr Biol
December 2024
Department of Biology, University of Pisa, Via Derna 1, 56126 Pisa, Italy; CoNISMa, Piazzale Flaminio 9, 00196 Rome, Italy.
Theory predicts that spatial modular networks contain the propagation of local disturbances, but field experimental tests of this hypothesis are lacking. We combined a field experiment with a metacommunity model to assess the role of modularity in buffering the spatial spread of algal turfs in three replicated canopy-dominated macroalgal networks. Experimental networks included three modules where plots with intact canopy cover (nodes) were connected through canopy-thinned corridors.
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