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Instruction-responsive programmable assemblies with DNA origami block pieces. | LitMetric

Instruction-responsive programmable assemblies with DNA origami block pieces.

Nucleic Acids Res

School of Computer Science and Cyber Engineering, GuangZhou University, 230 Wai Huan Xi Road, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.

Published: December 2024

AI Article Synopsis

Article Abstract

DNA nanotechnology has created a wide variety of nanostructures that provide a reliable platform for nanofabrication and DNA computing. However, constructing programmable finite arrays that allow for easy pre-functionalization remains challenge. We aim to create more standardized and controllable DNA origami components, which could be assembled into finite-scale and more diverse superstructures driven by instruction sets. In this work, we designed and implemented DNA origami building block pieces (DOBPs) with eight mutually independent programmable edges and formulated DNA instructions that tailored such components. This system enables DOBPs to be assembled into one or more specific 2D arrays according to the instruction sets. Theoretically, a two-unit system can generate up to 48 distinct DNA arrays. Importantly, experiments results demonstrated that DOBPs are capable of both deterministic and nondeterministic assemblies. Moreover, after examining the effects of different connection strategies and instruction implementations on the yield of the target structures, we assembled more complex 2D arrays, including limited self-assembly arrays such as 'square frames', 'windmills' and 'multiples of 3' long strips. We also demonstrated examples of Boolean logic gates 'AND' and 'XOR' computations based on these assembly arrays. The assembly system provides a model nano-structure for the research on controllable finite self-assembly and offers a more integrated approach for the storage and processing of molecular information.

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Source
http://dx.doi.org/10.1093/nar/gkae1193DOI Listing

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