Treatment Approaches to Myasthenia Gravis and Obstructive Sleep Apnea: Case Report.

Sleep Sci

Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.

Published: December 2024

AI Article Synopsis

  • Myasthenia gravis (MG) is an autoimmune disease that causes muscle weakness due to the destruction of acetylcholine receptors at the neuromuscular junction.
  • Treatment for patients with both MG and obstructive sleep apnea (OSA) often includes positive pressure airway therapy, but adherence to this treatment can be challenging, leading to worse health outcomes.
  • This report focuses on a case study of a 50-year-old man with MG and OSA, examining how he responded to various treatment methods.

Article Abstract

Myasthenia gravis (MG) is a chronic autoimmune disease characterized by progressive weakness and skeletal muscle fatigue due to the destruction of acetylcholine receptors, causing an abnormality in the synaptic junction between innervation and muscle fibers. The treatment of patients with MG and obstructive sleep apnea (OSA) is positive pressure in the airway; however, the lack of adherence to the protocol can lead to increased morbidity. A known alternative treatment for OSA is the mandibular advancement device (MAD). The objective of the present report is to describe an emblematic case of a 50-year-old male patient with MG with sleep complaints and documented OSA, and his response to different treatment approaches.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651833PMC
http://dx.doi.org/10.1055/s-0044-1780502DOI Listing

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