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| http://dx.doi.org/10.21037/tcr-24-952 | DOI Listing |
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PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition.
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Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan.
The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement in homologous recombination (HR), the impact of its overexpression on HR remains unclear. In this study, we investigated the effect of PLK1 overexpression on HR using bioinformatics and experimental approaches.
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Laboratory of Electromechanical Integrated Manufacturing of High-performance Electronic Equipment, School of Mechano-Electronic Engineering, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
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The Spatial Distribution of Brain Metastasis Is Determined by the Heterogeneity of the Brain Microenvironment.
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