AI Article Synopsis
- The study investigates how HIV infection and injection drug use affect the human microbiome by comparing the microbial communities of both HIV-positive and HIV-negative individuals in Puerto Rico, a region with high drug use and HIV rates.
- Using advanced genetic sequencing techniques, the researchers found significant differences in bacterial communities between drug injectors and non-injectors, particularly in the prevalence of certain bacterial genera.
- Results showed that HIV-positive individuals had a higher abundance of specific bacteria, while drug use impacted microbiome compositions differently for HIV-infected and non-infected subjects, indicating complex interactions between these factors.
Article Abstract
Introduction: The full extent of interactions between human immunodeficiency virus (HIV) infection, injection drug use, and the human microbiome is unclear. In this study, we examined the microbiomes of HIV-positive and HIV-negative individuals, both drug-injecting and non-injecting, to identify bacterial community changes in response to HIV and drug use. We utilized a well-established cohort of people who inject drugs in Puerto Rico, a region with historically high levels of injection drug use and an HIV incidence rate disproportionately associated with drug use.
Methods: Using amplicon-based 16S rDNA sequencing, we identified amplicon sequence variants (ASVs) that demonstrated significant variations in the composition of microbial communities based on HIV status and drug use.
Results And Discussion: Our findings indicate that the HIV-positive group exhibited a higher abundance of ASVs belonging to the genera , , , , , and . However, Bifidobacteria and ASVs were more abundant in injectors than in non-injectors. We examined the effect of drug use on the gut microbiome in both HIV-infected and non-infected patients, and found that multiple drug use significantly affected the microbial community composition. Analysis of differential of bacterial taxa revealed an enrichment of spp. spp., and spp. in the multiple drug-injecting group. However, in the non-injecting group, spp., spp., spp., spp., spp. The presence of multiple drug-injecting groups was observed to be more prevalent. Our findings provide detailed insight into ASV-level changes in the microbiome in response to HIV and drug use, suggesting that the effect of HIV status and drug injection may have different effects on microbiome composition and in modulating gut bacterial populations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652967 | PMC |
| http://dx.doi.org/10.3389/fmicb.2024.1470037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
We identified Prototheca spp. microalga in ocular samples of a cat in Spain with nontreatable endogenous endophthalmitis. Within 2 years, the eye lesions progressively worsened and neurologic signs appeared, suggesting systemic spread of the infection.
View Article and Find Full Text PDFAlbendazole/ivermectin combination therapy is a promising alternative to benzimidazole monotherapy alone for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris spp. populations in patient samples from Côte d'Ivoire showing lower (egg reduction rate <70%) albendazole/ivermectin sensitivity than those from Laos and Tanzania (egg reduction rates >98%).
View Article and Find Full Text PDFGenetic interaction analysis of transcription factors and in the regulation of respiration and fluconazole susceptibility.
Antimicrob Agents Chemother
December 2024
Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
is the second most common cause of invasive candidiasis and is widely known to have reduced susceptibility to fluconazole relative to many other spp. Upc2A is a transcription factor that regulates ergosterol biosynthesis gene expression under conditions of sterol stress such as azole drug treatment or hypoxia. Through an microevolution experiment, we found that loss-of-function mutants of the ATF/CREB transcription factor suppresses the fluconazole hyper-susceptibility of the ∆ mutant.
View Article and Find Full Text PDFIntegrated Data Mining and Animal Experiments to Investigate the Efficacy and Potential Pharmacological Mechanism of a Traditional Tibetan Functional Food . in Hyperuricemia.
J Inflamm Res
December 2024
School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
Background: Hyperuricemia (HUA), a common metabolic disorder associated with gout, renal dysfunction, and systemic inflammation, necessitates safer and more comprehensive therapeutic approaches. Traditional Tibetan medicine has a rich history of treating HUA. This study aimed to identify novel anti-hyperuricemic herb derived from traditional Tibetan medicine.
View Article and Find Full Text PDFUnlabelled: is a Gram-negative opportunistic pathogen that poses a significant public health threat, particularly in healthcare settings. A key determinant of virulence is the regulated synthesis and release of extracellular products, which is controlled by a cell density-dependent signaling system known as quorum sensing (QS). uses a complex QS network, including two systems that rely on diffusible N-acylhomoserine lactone (AHL) signal molecules.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!