AI Article Synopsis

  • * A study of 1,011 patients showed that those with bacterial infections had a much higher rate of progression to decompensated cirrhosis (44.9%) compared to those without infections (9%).
  • * The research indicates that bacterial infections significantly increase the risk of worsening liver conditions in patients with compensated cirrhosis, highlighting the importance of monitoring and treating infections in these patients.

Article Abstract

Background: Hepatitis B virus related compensated cirrhosis generally has a favorable prognosis until decompensation occurs. Bacterial infections are prevalent in Hepatitis B virus related decompensated cirrhosis.Bacterial infection and decompensated hepatitis B cirrhosis are mutually reinforcing. And it also interacts with and promotes certain decompensation-related events. However, the impact of bacterial infections on the progression from compensated to decompensated cirrhosis in Hepatitis B patients remains unclear.

Methods: We retrospectively analyzed the baseline characteristics of 1,011 patients with Hepatitis B virus related compensated cirrhosis. Using time-dependent regression analysis, we evaluated whether bacterial infections increase the risk of decompensation, defined as the occurrence of ascites, hepatic encephalopathy, or variceal bleeding.

Results: A total of 1,011 patients were retrospectively analyzed over a median follow-up period of 79 months. Bacterial infections were observed in 89 patients (8.8%). Respiratory and urinary tract infections were the most common bacterial infections.Decompensation occurred in 44.9% of patients with bacterial infections, compared to 9% of those without BIs. Patients with bacterial infections had a higher risk of decompensation ([OR] 1.024; 95% CI 1.016-1.032; p < 0.001) than those without bacterial infections.

Conclusion: Our findings suggest that bacterial infections have a significant impact on the progression of hepatitis B virus related compensated cirrhosis, notably increasing the risk of decompensation.

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Source
http://dx.doi.org/10.1186/s12879-024-10306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657233PMC

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