Objective This study investigated the effects of role stressors on anxiety, depression, and subjective well-being (SWB), emphasizing primary appraisal.Methods A web-based survey was conducted with 2,000 full-time employees in November 2023. The sample included 1,093 males and 907 females aged 20-64 years (mean (M)=43.28, standard deviation (SD)=11.96). Survey items included attributes (sex, age, occupation, and position), role stressors, primary appraisal (irrelevant, positive, harm/loss, threat, and challenge), anxiety, depression, and SWB. We conducted a stepwise multiple regression analysis with primary appraisals as the dependent variable and role stressors and attributes as independent variables. Thereafter, we conducted a stepwise multiple regression analysis with anxiety, depression, and SWB as dependent variables and primary appraisals of role stressors and attributes as independent variables.Results Valid responses were obtained from 1,260 participants employed in sales and clerical work (valid response rate: 63.0%). The final sample included 548 males and 712 females aged 20-64 years (M=44.75, SD=11.61). Based on the results, positive, harm/loss, threat, and challenge appraisal positively influenced "role unclearly" and "role overload." Moreover, anxiety positively influenced "harm/loss" and "threat" appraisals but negatively influenced "challenge" appraisals. Furthermore, depression positively influenced "harm/loss" and "threat" appraisals but negatively influenced "challenge" appraisals. Conversely, SWB positively influenced "positive" and "challenge" appraisals but negatively influenced "harm/loss" appraisals in role unclearly and "harm/loss" and "threat" appraisals in role overload.Conclusion The anxiety, depression, and SWB of full-time employees in sales or clerical work were correlated with their primary appraisals of role stressors.
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http://dx.doi.org/10.11236/jph.24-049 | DOI Listing |
Environ Res
January 2025
Key laboratory of Exploration and Utilization of Aquatic Genetic Resources of the Ministry of Education, Engineering Research Center of Environmental DNA and Ecological Water Health Assessment, Shanghai Ocean University, Shanghai 201306, China. Electronic address:
Global change stressors, including climate warming, eutrophication, and small-sized omnivorous fish, may exert interactive effects on the food webs and functioning of shallow lakes. Periphyton plays a central role in the primary production and nutrient cycling of shallow lakes but constitutes a complex community composed of eukaryotes and prokaryotes that may exhibit different responses to multiple environmental stressors with implications for the projections of the effects of global change on shallow lakes. We analyzed the effects of warming, nutrient enrichment, small omnivorous fish and their interactions on eukaryotic and prokaryotic periphyton structures in shallow lake mesocosms.
View Article and Find Full Text PDFBacteria can change morphology in response to stressors and changes in their environment, including infection of a host. We previously identified the bacterial species, , which uses nutrient-induced filamentation as a novel mechanism for cell-to-cell spreading in the intestinal epithelial cells of a nematode host. To further investigate the conservation of nutrient-induced filamentation in Bordetellae, we utilized the turkey-infecting species which filaments in vitro when switched from a standard growth media to an enriched media.
View Article and Find Full Text PDFAutophagy is an essential cellular process which functions to maintain homeostasis in response to stressors such as starvation or infection. Here, we report that a subset of autophagy factors including ATG-3 play an antiviral role in Orsay virus infection of . Orsay virus infection does not modulate autophagic flux, and re-feeding after starvation limits Orsay virus infection and blocks autophagic flux, suggesting that the role of ATG-3 in Orsay virus susceptibility is independent of its role in maintaining autophagic flux.
View Article and Find Full Text PDFCogn Neurodyn
December 2025
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Institute of Health and Rehabilitation Science, Xi'an Jiaotong University, Xi'an, 710049 Shaanxi China.
The locus coeruleus (LC), as the primary source of norepinephrine (NE) in the brain, is central to modulating cognitive and behavioral processes. This review synthesizes recent findings to provide a comprehensive understanding of the LC-NE system, highlighting its molecular diversity, neurophysiological properties, and role in various brain functions. We discuss the heterogeneity of LC neurons, their differential responses to sensory stimuli, and the impact of NE on cognitive processes such as attention and memory.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Department of Biochemistry and Molecular Biology, College of Medicine, Center for Epigenetics, Genetics Institute, UF Health Cancer Center, Powell-Gene Therapy Center, University of Florida, Gainesville, Florida 32610. Electronic address:
Transcription factor TFII-I/GTF2I is ubiquitously expressed and has been shown to play a role in the differentiation of hematopoietic cells and in the response to various cellular stressors. We previously demonstrated that TFII-I acts as a repressor of adult β-globin gene transcription and positively regulates expression of stress response proteins, including ATF3. Here we analyzed the function of TFII-I in TF-1 cells during erythroid differentiation and in response to cellular stress, including unfolded protein response, hypoxia, and oxidative stress.
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