AI Article Synopsis
- The study focuses on the genus Daphne, specifically Daphne pseudomezereum, which has not been previously researched for its anti-HIV diterpenoids.
- Three new compounds, onishibarins A-C, were discovered alongside seven known ones from the plant's fruits.
- The new compounds showed significant anti-HIV activity, with some having low effective concentrations and minimal cytotoxicity.
Article Abstract
The plants of the genus Daphne (Thymelaeaceae) are known to be sources of anti-HIV diterpenoids. Therefore, the present study focused on investigating the anti-HIV diterpenoids in Daphne pseudomezereum, for which the isolation of diterpenoids has not been previously reported. The results showed that three previously undescribed daphnane diterpenoids, onishibarins A-C (1-3), along with seven known compounds (4-10) were isolated from the fruits of Daphne pseudomezereum. Their structures were established by comprehensive analysis of physicochemical and spectroscopic data. Evaluation of the anti-HIV activity and cytotoxicity of the isolated compounds showed that compounds 1, 9, and 10 exhibited potent anti-HIV activity at EC = 1.26, 0.84, and 0.78 nM, respectively, with cytotoxicity at IC > 5 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2024.114366 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anti-HIV diterpenoids from Daphne pseudomezereum.
Phytochemistry
December 2024
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan. Electronic address:
Article Synopsis
- The study focuses on the genus Daphne, specifically Daphne pseudomezereum, which has not been previously researched for its anti-HIV diterpenoids.
- Three new compounds, onishibarins A-C, were discovered alongside seven known ones from the plant's fruits.
- The new compounds showed significant anti-HIV activity, with some having low effective concentrations and minimal cytotoxicity.
Mechanisms and efficacy of small molecule latency-promoting agents to inhibit HIV reactivation ex vivo.
JCI Insight
August 2024
Department of Medicine, University of California San Francisco (UCSF), San Francisco, California, USA.
Drugs that inhibit HIV transcription and/or reactivation of latent HIV have been proposed as a strategy to reduce HIV-associated immune activation or to achieve a functional cure, yet comparative studies are lacking. We evaluated 26 drugs, including drugs previously reported to inhibit HIV transcription (inhibitors of Tat-dependent HIV transcription, Rev, HSF-1/PTEF-b, HSP90, Jak/Stat, or SIRT1/Tat deacetylation) and other agents that were not tested before (inhibitors of PKC, NF-κB, SP-1, or histone acetyltransferase; NR2F1 agonists), elongation (inhibitors of CDK9/ PTEF-b), completion (inhibitors of PolyA-polymerase), or splicing (inhibitors of human splice factors). To investigate if those drugs would vary in their ability to affect different blocks to HIV transcription, we measured levels of initiated, elongated, midtranscribed, completed, and multiply spliced HIV RNA in PBMCs from antiretroviral therapy-suppressed individuals following ex vivo treatment with each drug and subsequent T cell activation.
View Article and Find Full Text PDFAbietane diterpenoids from Isodon amethystoides and their biological activities.
Phytochemistry
September 2024
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, PR China. Electronic address:
Seven undescribed abietane diterpenoids [abietamethinols A-G (1-7)] were isolated from the twigs and leaves of Isodon amethystoides. Their structures were elucidated on the basis of spectroscopic methods including 2D NMR, and they were further confirmed by X-ray crystallographic data. Lophanic acid was considered as the precursor of 1-7 in the biosynthesis pathway hypothesis.
View Article and Find Full Text PDFDaphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata.
J Nat Med
September 2024
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
Daphnane diterpenoids were recognized for their extensive range of potent biological activities. In the present study, phytochemical investigation including LC-MS/MS analysis resulted in the identification of five daphnane diterpenoid orthoesters (1-5). Among the five daphnane diterpenoids, two previously unreported compounds, daphnepedunins I and J (2 and 4) were isolated from Daphne pedunculata.
View Article and Find Full Text PDFSeco-cyclic phorbol derivatives and their anti-HIV-1 activities.
Chin J Nat Med
April 2024
College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. Electronic address:
Article Synopsis
- * Research involved modifying phorbol to create seco-cyclic derivatives and testing their ability to inhibit HIV-1 while measuring their affinity for PKC-δ protein.
- * The standout compound, S11, showed strong anti-HIV-1 properties but did not bind to PKC-δ, indicating it could be a promising candidate for further research in developing HIV treatments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!