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Function: insertAPISummary
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Filename: controllers/Detail.php
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Function: require_once
Cyclins are a group of proteins that regulate the cell cycle process by modulating various stages of cell division to ensure correct cell proliferation, differentiation, and apoptosis. Research on cyclins is crucial for understanding the biological functions and pathological states of cells. However, current research on cyclin identification based on machine learning only focuses on accuracy ignoring the interpretability of features. Therefore, in this study, we pay more attention to the interpretation and analysis of key features associated with cyclins. Firstly, we developed an SVM-based model for identifying cyclins with an accuracy of 92.8% through 5-fold. Then we analyzed the physicochemical properties of the 14 key features used in the model construction and identified the G and charged C1 features that are critical for distinguishing cyclins from non-cyclins. Furthermore, we constructed an SVM-based model using only these two features with an accuracy of 81.3% through the leave-one-out cross-validation. Our study shows that cyclins differ from non-cyclins in their physicochemical properties and that using only two features can achieve good prediction accuracy.
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http://dx.doi.org/10.1016/j.ymeth.2024.12.009 | DOI Listing |
Nucleic Acids Res
December 2024
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) OT Gatersleben, Corrensstr 3, 06466 Seeland, Germany.
In eukaryotes, accurate chromosome segregation during cell division relies on the centromeric histone H3 variant, CENH3. Our previous work identified KINETOCHORE NULL2 (αKNL2) as a plant CENH3 assembly factor, which contains a centromere-targeting motif, CENPC-k, analogous to the CENPC motif found in CENP-C. We also demonstrated that αKNL2 can bind DNA in vitro in a sequence-independent manner, without the involvement of its CENPC-k motif.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.
G-quadruplexes (G4s), as an important type of non-canonical nucleic acid structure, have received much attention because of their regulations of various biological processes in cells. Identifying G4s-protein interactions is essential for understanding G4s-related biology. However, current strategies for exploring G4 binding proteins (G4BPs) include pull-down assays in cell lysates or photoaffinity labeling, which are lack of sufficient spatial specificity at the subcellular level.
View Article and Find Full Text PDFACS Chem Biol
December 2024
UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Tudor domains are histone readers that can recognize various methylation marks on lysine and arginine. This recognition event plays a key role in the recruitment of other epigenetic effectors and the control of gene accessibility. The Tudor-containing protein family contains 42 members, many of which are involved in the development and progression of various diseases, especially cancer.
View Article and Find Full Text PDFBioinformatics
December 2024
Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, A-1030, Austria.
Motivation: The efficient and reproducible analysis of high-throughput sequencing datasets necessitates the development of methodical and robust computational pipelines that integrate established and bespoke bioinformatics analysis tools, often written in high-level programming languages such as Python. Despite the increasing availability of programming libraries for genomics, there is a noticeable lack of tools specifically focused on transcriptomics. Key tasks in this area include the association of gene features (e.
View Article and Find Full Text PDFDiscov Nano
December 2024
Department of Instrumentation and Control Engineering, Dr B R Ambedkar National Institute of Technology Jalandhar, Punjab, 144008, India.
In vivo, molecular imaging is prevalent for biology research and therapeutic practice. Among advanced imaging technologies, photoacoustic (PA) imaging and sensing is gaining interest around the globe due its exciting features like high resolution and good (~ few cm) penetration depth. PA imaging is a recent development in ultrasonic technology that generates acoustic waves by absorbing optical energy.
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