Sacrificial templating offers the ability to create interconnected pores within 3D printed filaments and to control pore morphology. Beta-tricalcium phosphate (TCP) bone tissue engineering (BTE) scaffolds were fabricated with multiscale porosity: (i) macropores from direct ink writing (DIW, a material extrusion 3D printing technique), (ii) micropores from oil templating, and (iii) smaller micropores from partial sintering. The hierarchically porous scaffolds possessed a total porosity of 58-70 %, comprising 54-63 % interconnected open pores. The in vitro results demonstrated that scaffolds with macroporosity promoted human osteoblast growth more than scaffolds with only microporosity. The elongated pores from the capillary suspension filament microstructure induced greater cell spreading than the sphere-like pores from the emulsion. Overall, the hierarchically porous scaffold with capillary suspension TCP filaments provided a superior microenvironment for significantly higher cell viability and proliferation than the other scaffolds, including a poly(ε-caprolactone) (PCL) control, a material currently used clinically as porous BTE scaffolds. The cellular response was further enhanced when macropore size was in the range of 570-590 μm. Therefore, the hierarchically porous scaffolds in this study are promising as BTE scaffolds, and the reported process of DIW of oil-templated colloidal pastes is a feasible strategy with potential for further customization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bioadv.2024.214149 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Porous Organic Polymers Incorporating Shape-persistent Cyclobenzoin Macrocycles for Organic Solvent Separation.
Angew Chem Int Ed Engl
January 2025
University of Fribourg: Universite de Fribourg, Department of Chemistry, Chemin du Musée 9, 1700, Fribourg, SWITZERLAND.
The recovery and separation of organic solvents is highly important for the chemical industry and environmental protection. In this context, porous organic polymers (POPs) have significant potential owing to the possibility of integrating shape-persistent macrocyclic units with high guest selectivity. Here, we report the synthesis of a macrocyclic porous organic polymer (np-POP) and the corresponding model compound by reacting cyclotetrabenzil naphthalene octaketone macrocycle with 1,2,4,5-tetraaminobenzene and 1,2-diaminobenzene, respectively, under solvothermal conditions.
View Article and Find Full Text PDFFish scale gelatin/diatom biosilica composite hemostasis sponge with ultrafast dispersing and in situ gelation for hemorrhage control.
Int J Biol Macromol
January 2025
College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, Shandong Province, China; Sanya Oceanographic Institute, Ocean University of China, Floor 7, Building 1, Yonyou Industrial Park, Yazhou Bay Science & Technology City, Sanya, Hainan Province, China. Electronic address:
Rapid control of hemorrhage is vital in first-aid and surgery. As representative of emergency hemostatic materials, inorganic porous materials achieve rapid hemostasis through concentrating protein coagulation factors by water adsorption to accelerate the coagulation reaction process, however their efficacy is often limited by the insufficient contact of material with blood and the lack of blood clot strength. Herein, we report an ultrafast dispersing and in situ gelation sponge (SG/DB) based on anchoring interface effect for hemorrhage control using freeze drying method after mixing fish scale gel (SG) and tert-butyl alcohol (TBA) pre-crystallized diatom biosilica (DB).
View Article and Find Full Text PDFPreparation of nitrogen-doped biocarbon from sewage sludge and pine sawdust for superior hydrogen sulfide removal: Experimental and DFT studies.
Environ Res
January 2025
Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, China; CAS Key Laboratory of Renewable Energy, Guangzhou 510640, China; Guangdong Provincial Key Laboratory of High-Quality Recycling of End-of-Life New Energy Devices, Guangzhou 510640, China. Electronic address:
Hydrogen sulfide (HS) is a major air pollutant posing a serious threat to both the environment and public health. In this study, a novel nitrogen-rich biocarbon that effectively removes HS was produced from a mixture of sewage sludge and pine sawdust using melamine as nitrogen source. Compared with pristine biocarbons, nitrogen (N)-doped biocarbons possessed an adjustable porosity, e.
View Article and Find Full Text PDFTailoring the Porous Structure of Carbon for Enhanced Oxidative Cleavage and Esterification of C(CO)-C Bonds.
ChemSusChem
December 2024
National & Local Joint Engineering Research Center on Biomass Resource Utilization, College of Environmental Science and Engineering, Nankai University, Tianjin, 300350, P. R. China.
The cleavage and functionalization of carbon-carbon bonds are crucial for the reconstruction and upgrading of organic matrices, particularly in the valorization of biomass, plastics, and fossil resources. However, the inherent kinetic inertness and thermodynamic stability of C-C σ bonds make this process challenging. Herein, we fabricated a glucose-derived defect-rich hierarchical porous carbon as a heterogeneous catalyst for the oxidative cleavage and esterification of C(CO)-C bonds.
View Article and Find Full Text PDF2D Titanium Carbide MXene-Interfaced Zinc Oxide/Tungstite Architectures Adorned Mixed Matrix Polymer Membranes for Oily Wastewater Treatment.
ACS Appl Mater Interfaces
January 2025
Department of Physics, National Institute of Technology Nagaland, Chumukedima, Dimapur 797103, India.
An exceedingly porous and interwoven fibrous structure was achieved in this study by interlocking titanium carbide (TiC) MXenes onto the electrospun mats using poly(vinylidene fluoride) (PVDF) as the base polymer. The fibrous membrane was further modified with the inclusion of zinc oxide (ZnO) and tungstite (WO·HO) nano/microstructures via annealing and hydrothermal approaches. Through these strategic interfaced morphological developments in novel TiC/ZnO/WO·HO heterostructures, our findings reveal enhanced wettability and charge-segregation desirable for promoting oil-water separation and photoreactivity, respectively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!