AI Article Synopsis
- Granuloma annulare (GA) is a non-infectious skin condition that can become widespread in some patients; this study focused on those with disseminated GA in a German hospital.
- A total of 239 patients were studied, with 33 having confirmed disseminated GA, predominantly affecting women around the age of 57, and many reporting little to no symptoms.
- Treatment options included glucocorticoids and phototherapy, but only a small percentage achieved remission, highlighting the need for more effective clinical trials for new therapies.
Article Abstract
Background And Objectives: Granuloma annulare (GA) is a noninfectious, granulomatous dermatosis that is generally localized and self-limiting. In 15% of cases, the disease disseminates with protracted trajectories. This study aims to characterise the patient population with disseminated GA at a German university hospital and to explore treatment modalities.
Materials And Methods: A retrospective monocentric evaluation was conducted at the University Hospital Regensburg between 2021 and 2023 with descriptive statistical analysis of the patient population and the treatment modalities used.
Results: During the specified period, 239 patients with GA were identified, 33 of whom had histologically confirmed disseminated GA. Of the patients, 25 (76%) were women. Average age was 57.4 ± 14.4 years. Furthermore 17 patients (53%) denied symptoms. Common symptoms included dysesthesia, itching and pain. Frequent concomitant diseases were diabetes mellitus, thyroid disease, atopic dermatitis and coronary heart disease. Topical glucocorticoids, systemic glucocorticoids, phototherapy, topical calcineurin inhibitors and dimethyl fumarate were used therapeutically in descending frequency. Only 6 patients (18%) showed partial or complete remission.
Conclusion: Due to the lack of approved therapies, disseminated GA is treated with inadequately effective regimens. Prospective randomized placebo-controlled trials are needed to investigate the efficacy of novel targeted therapies.
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| http://dx.doi.org/10.1007/s00105-024-05436-2 | DOI Listing |
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