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Synergistic combinations of for myocardial infarction treatment: network pharmacology and quadratic optimization approach.
Front Pharmacol
December 2024
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Background And Aim: (Oliv.) Diels (Danggui, DG), exhibits potential in myocardial infarction (MI) treatment. However, research on its synergistic combinations for cardioprotective effects has been limited owing to inadequate approaches.
View Article and Find Full Text PDFIL-1R2 Expression in Tfr Cells Controls Allergic Anaphylaxis by Regulating IgG Versus IgE Responses.
Allergy
December 2024
Sorbonne Université, INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy, i3, Paris, France.
A New Easy-to-Perform Flow Cytometry Assay for Determining Bacterial- and Viral-Infection-Induced Polymorphonuclear Neutrophil and Monocyte Membrane Marker Modulation in Febrile Patients.
Int J Mol Sci
October 2024
Laboratory of Oncology and Flow Cytometry, A. Gemelli University Hospital Foundation IRCCS, 00168 Rome, Italy.
We developed a flow cytometry (FC) assay enabling the rapid and accurate identification of bacterial and viral infections using whole blood samples. The streamlined flow cytometry assay is designed to be user-friendly, making it accessible even for operators with limited experience in FC techniques. The key components of the assay focus on the expression levels of specific surface markers-CD64 on polymorphonuclear neutrophils (PMN) as a marker for bacterial infection, and CD169 on monocytes (MO) for viral infection.
View Article and Find Full Text PDFIL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance.
Immune Netw
June 2024
Laboratory of Autoimmunity and Inflammation (LAI), Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
IL-1, a pleiotropic cytokine with profound effects on various cell types, particularly immune cells, plays a pivotal role in immune responses. The proinflammatory nature of IL-1 necessitates stringent control mechanisms of IL-1-mediated signaling at multiple levels, encompassing transcriptional and translational regulation, precursor processing, as well as the involvement of a receptor accessory protein, a decoy receptor, and a receptor antagonist. In T-cell immunity, IL-1 signaling is crucial during both the priming and effector phases of immune reactions.
View Article and Find Full Text PDFDifferences in microenvironment of lung cancer and pleural effusions by single-cell RNA sequencing.
Lung Cancer
July 2024
Duke Immune Profiling Core, Department of Surgery, Duke University, Durham, NC, USA.
Background: Direct comparison of tumor microenvironment of matched lung cancer biopsies and pleural effusions (PE) from the same patients is critical in understanding tumor biology but has not been performed. This is the first study to compare the lung cancer and PE microenvironment by single-cell RNA sequencing (scRNA-seq).
Methods: Matched lung cancer biopsies and PE were obtained prospectively from ten patients.
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