Umbilical endometriosis is defined as an ectopic localization of functional endometrium at the level of the umbilicus. It is a rare condition, representing 0.5% to 1% of all extragenital endometriosis cases, and its pathophysiology is poorly understood. We report the case of a 34-year-old woman, G2P2, with no significant surgical history, admitted for cyclic umbilical pain. Physical examination revealed a grayish nodule at the umbilicus and MRI showed a parietal umbilical nodule suggestive of an endometrioma. The patient underwent resection of the umbilical nodule and the definitive histological study confirmed endometriosis.
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http://dx.doi.org/10.1016/j.radcr.2024.10.146 | DOI Listing |
Radiol Case Rep
February 2025
Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco.
Int Med Case Rep J
December 2024
Gynecology and Obstetric Department, Kabul University of Medical Science, Shahr Ara University Hospital, Kabul, Afghanistan.
Primary umbilical endometriosis is a rare condition in which there is endometrial glands and stroma in the umbilicus. Primary umbilical endometriosis is also called villar's nodule. This condition is a diagnostic challenge, the pathophysiology of the disease is not well defined and should be considered in all other pathologies of the umbilicus.
View Article and Find Full Text PDFRare Tumors
September 2024
Department of Surgery, University of Calabar/University of Calabar Teaching Hospital, Calabar, Nigeria.
Proc Natl Acad Sci U S A
September 2024
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom.
Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in nonhormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in the pathophysiology of endometriosis and represent a promising therapeutic target.
View Article and Find Full Text PDFJ Mol Med (Berl)
November 2024
Department of Gynaecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRNAs (miRNAs) in endometriosis is not well understood. This study investigates differentially expressed exosomal miRNAs linked to angiogenesis in endometriosis, clarifies their molecular mechanisms, and identifies potential targets.
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