Introduction: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.
Methods: Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.
Results: The study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.
Discussion: These findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649647 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1498139 | DOI Listing |
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