AI Article Synopsis
- The direct functionalization of C-H bonds has transformed synthetic organic chemistry, allowing for efficient modifications of arenes without the need for prefunctionalization.
- Innovative methods, particularly photoredox catalysis using transition metal and organic photocatalysts, have tackled challenges related to the inertness and regioselectivity of C-H bonds.
- This review presents recent advancements in regioselective C-H functionalization, focusing on strategies for achieving selectivity, mechanistic insights, and novel methodologies that enhance the scope of C-H bond modifications.
Article Abstract
The direct functionalization of C-H bonds has revolutionized the field of synthetic organic chemistry by enabling efficient and atom-economical modification of arenes by avoiding prefunctionalization. However, the inherent challenges of inertness and regioselectivity in different C-H bonds, particularly for distal positions, necessitate innovative approaches. In this aspect, photoredox catalysis by utilizing both transition metal and organic photocatalysts has emerged as a powerful tool for addressing these challenges under mild reaction conditions. This review provides a comprehensive overview of recent progress in regioselective C-H functionalization in arenes photocatalysis. Emphasizing the strategies for achieving , , and -selectivity, we explore the mechanistic insights, catalyst designs, and the novel methodologies that have expanded the scope of C-H bond functionalization. This discussion aims to offer valuable perspectives for advancing the field and developing more efficient and sustainable synthetic methodologies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647916 | PMC |
| http://dx.doi.org/10.1039/d4sc07491b | DOI Listing |
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