Abnormal microRNA expression profile at early stages of gestation in pregnancies destined to develop placenta previa.

Front Med (Lausanne)

Institute for the Care of the Mother and Child, Third Faculty of Medicine, Charles University, Prague, Czechia.

Published: December 2024

AI Article Synopsis

  • Placenta previa is a condition where the placenta implants abnormally in the lower uterus, leading to serious risks for both the mother and fetus, including hemorrhage and stillbirth.
  • This study focused on analyzing microRNA expression in the blood during the first trimester of pregnancies that later developed placenta previa, comparing them to normal pregnancies.
  • The results showed that several microRNAs were downregulated in those pregnancies, with a combination of seven specific microRNAs accurately distinguishing between healthy and placenta previa pregnancies early on.

Article Abstract

Background: Placenta previa is the abnormal implantation of the placenta into the lower segment of the uterus, is associated with adverse maternal and fetal outcomes such as placenta accreta spectrum disorders, antepartum and postpartum hemorrhage, fetal growth restriction, prematurity, stillbirth and neonatal death, thrombophlebitis, and septicemia. The aim of the study was to assess retrospectively how the later onset of placenta previa affects the microRNA expression profile in the whole peripheral blood during the first trimester of gestation.

Methods: Regarding the occurrence of the association between aberrant microRNA expression profiles at early stages of gestation and later onset of various pregnancy-related complications, we selected for the study pregnancies developing placenta previa as the only pregnancy-related disorder. In total, 24 singleton pregnancies diagnosed with placenta previa that underwent first-trimester prenatal screening and delivered on-site within the period November 2012-May 2018 were included in the study. Overall, 80 normal pregnancies that delivered appropriate-for-gestational age newborns after completing 37 weeks of gestation were selected as the control group based on the equality of the length of biological sample storage.

Results: Downregulation of multiple microRNAs (miR-20b-5p, miR-24-3p, miR-26a-5p, miR-92a-3p, miR-103a-3p, miR-130b-3p, miR-133a-3p, miR-145-5p, miR-146a-5p, miR-155-5p, miR-181a-5p, miR-195-5p, miR-210-3p, miR-342-3p, and miR-574-3p) was observed in pregnancies destined to develop placenta previa. The combination of seven microRNAs (miR-130b-3p, miR-145-5p, miR-155-5p, miR-181a-5p, miR-210-3p, miR-342-3p, and miR-574-3p) showed the highest accuracy (AUC 0.937, < 0.001, 100.0% sensitivity, 83.75% specificity) to differentiate, at early stages of gestation, between pregnancies with a normal course of gestation and those with placenta previa diagnosed in the second half of pregnancy. Overall, 75% of pregnancies destined to develop placenta previa were correctly identified at 10.0% FPR.

Conclusion: Consecutive large-scale analyses must be performed to verify the reliability of the proposed novel early predictive model for placenta previa occurring as the only pregnancy-related disorder.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650449PMC
http://dx.doi.org/10.3389/fmed.2024.1469855DOI Listing

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Abnormal microRNA expression profile at early stages of gestation in pregnancies destined to develop placenta previa.

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  • This study focused on analyzing microRNA expression in the blood during the first trimester of pregnancies that later developed placenta previa, comparing them to normal pregnancies.
  • The results showed that several microRNAs were downregulated in those pregnancies, with a combination of seven specific microRNAs accurately distinguishing between healthy and placenta previa pregnancies early on.
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