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Nicardipine-Induced Acute Hypoxia in a Patient With Type B Aortic Dissection.
JACC Case Rep
December 2024
Department of Internal Medicine, University of California-San Francisco School of Medicine, San Francisco, California, USA.
Hypoxic pulmonary vasoconstriction (HPV) is a major physiological mechanism that prevents the development of hypoxemia secondary to a regional decrease in the ventilation-perfusion ratio (the intrapulmonary shunt effect). Calcium plays a critical role in the cellular response to hypoxia and the regulation of the pulmonary vascular tone. Therefore, calcium channel antagonists such as nicardipine have the potential to interfere with the pulmonary response to hypoxia, increasing intrapulmonary blood shunt and thus worsening underlying hypoxemia.
View Article and Find Full Text PDFBlood flow autoregulation in cerebral white matter was measured before and after acute nicardipine-induced changes in mean arterial pressure of 10-21% in 21 treatment naïve HIV-positive adults and 32 controls. The autoregulatory index (-% cerebral blood flow change/% mean arterial pressure change) was not different at baseline ( P = 0.71) or after 1 year of treatment ( n = 11, P = 0.
View Article and Find Full Text PDFBradycardia caused by intravenous nicardipine in an elderly patient with acute ischemic infarct.
Am J Emerg Med
April 2016
Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115. Electronic address:
Nicardipine is a dihydropyridine calcium-channel blocker that is frequently used in the acute treatment of hypertension in the emergency department (ED). Reflex sympathetic tachycardia is a well-described side effect of this medication. Two experimental studies and 1 anesthesia case report, however, have previously described nicardipine-induced bradycardia as a very rare side effect.
View Article and Find Full Text PDFNicardipine-induced acute pulmonary edema: a rare but severe complication of tocolysis.
Case Rep Crit Care
September 2014
Service de Réanimation Polyvalente, CIC 0801, CHU Dupuytren, 02 avenue Martin Luther King, 87000 Limoges, France.
We report four cases of acute pulmonary edema that occurred during treatment by intravenous tocolysis using nicardipine in pregnancy patients with no previous heart problems. Clinical severity justified hospitalization in intensive care unit (ICU) each time. Acute dyspnea has begun at an average of 63 hours after initiation of treatment.
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