AI Article Synopsis
- The study investigates how thrombolytic therapy and endovascular thrombectomy affect certain blood markers related to brain damage in patients who had an acute ischemic stroke.
- Results showed significant changes in S100B and thiol levels in the thrombolytic therapy group, indicating a potential reduction in brain injury, whereas the levels of disulfide and ischemia-modified albumin didn't significantly change.
- The findings emphasize the need for further research to explore treatments that mitigate free radical damage during stroke recovery.
Article Abstract
Background: A variety of processes, ranging from blood-brain barrier disruption to circulating biomarkers, contributes to reperfusion injury in acute stroke treatment.
Objective: We aimed to investigate the effects of thrombolytic therapy and endovascular thrombectomy therapy on serum S100 calcium-binding protein B, ischemia-modified albumin and thiol-disulfide balance in patients who arrived within the first 6 h of acute ischemic stroke.
Material And Methods: The study considered 66 patients with the diagnosis of acute ischemic stroke who underwent thrombolytic therapy or EVT in the first 6 h, as well as 32 healthy volunteers. Venous blood samples were collected before tPA and EVT and 24 h after treatment. S100B, native thiol, disulfide, total thiol, and Ischemia-modified albumin (IMA) levels were measured.
Results: The S100B, total thiol, and native thiol values of the patients in the tPA group before and after the treatment showed statistical significance (P < 0.001). S100B, total thiol, and native thiol values were shown to be lower. The disulfide and IMA values of the patients in the tPA group did not differ significantly (respectively, P = 0.302, P = 0.054). However, disulfide and IMA levels were found to increase after treatment compared to pretreatment. The patients in the EVT group showed a significant difference in terms of S100B values (P < 0.001) and IMA values (P = 0.024).
Conclusions: Determining how to protect the brain from free radical damage is important. More research should be carried out on treatments that prevent free radical damage in ischemia-reperfusion injury, as well as treatments for acute ischemic stroke.
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| http://dx.doi.org/10.4103/ni.ni_511_22 | DOI Listing |
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