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Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.
Arterioscler Thromb Vasc Biol
January 2025
Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston. (B.C.-C., N.A.V.G., N.L.P., L.P.E., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.).
Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease, mitigating immune responses can decrease inflammation and slow atherosclerosis progression.
View Article and Find Full Text PDFCurrent Strategies in Developing Antibacterial Surfaces for Joint Arthroplasty Implant Applications.
Materials (Basel)
January 2025
Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy.
Prosthetic joint infections (PJIs) remain a significant challenge, occurring in 1% to 2% of joint arthroplasties and potentially leading to a 20% to 30% mortality rate within 5 years. The primary pathogens responsible for PJIs include Staphylococcus aureus, coagulase-negative staphylococci, and Gram-negative bacteria, typically treated with intravenous antibiotic drugs. However, this conventional approach fails to effectively eradicate biofilms or the microbial burden in affected tissues.
View Article and Find Full Text PDF"I'm Not Who I Used to Be!" The Compelled Metamorphosing Process of Coping with Brucellosis Among Chinese Patients: A Qualitative Study.
Healthcare (Basel)
December 2024
Xiangya School of Nursing, Central South University, Changsha 410083, China.
Background: Brucellosis, one of the most common zoonotic diseases globally, is a serious public health problem. The complex and diverse clinical manifestations pose numerous challenges for patients when coping with brucellosis. Scarce studies have been performed in China.
View Article and Find Full Text PDFPrecision medicine using molecular-target drugs in psoriatic arthritis.
Ther Adv Musculoskelet Dis
January 2025
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu 807-8555, Japan.
Article Synopsis
- Psoriatic arthritis (PsA) has a range of symptoms like skin lesions, joint pain, and increased risk of cardiovascular issues, highlighting its complexity and impact on lifestyle.
- Molecular-targeted therapies have been developed that focus on key inflammatory pathways and are now commonly used to manage PsA symptoms, though treatment options can be limited.
- The shift towards precision medicine, using patient stratification based on blood tests and cytokine levels, aims to enhance treatment efficacy, but more data and new trial designs are essential for its success.
Catalytic Oxidation of Acetone over MnO-SiO Catalysts: An Effective Approach to Valorize Rice Husk Waste.
Materials (Basel)
December 2024
Área Fisicoquímica, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo 11800, Uruguay.
Rice husk, a byproduct of rice production, poses significant environmental challenges due to disposal issues, while the emission of volatile organic compounds into the atmosphere further exacerbates these concerns. This study addresses both problems by exploring the potential of texturally enhanced SiO, derived from Uruguayan rice husk, as a catalytic support for manganese oxides in the combustion of volatile organic compounds. SiO was synthesized from rice husk ash using a sustainable, acid-free pretreatment method, yielding a notably high silica purity of 96.
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