Dobutamine induced multifocal myoclonus in a patient with chronic kidney disease.

BMJ Case Rep

Department of Cardiac Thoracic and Vascular Anesthesia, JSS Medical college and Hospital, Mysore, Karnataka, India.

Published: December 2024

Adverse drug reactions (ADRs) are common in clinical practice, especially among patients with multiple comorbidities and polypharmacy. The ADRs associated with medications may be minor or life-threatening. Many available ADR assessment scales and pharmacovigilance programmes have streamlined the early diagnosis and management of ADRs. Dobutamine is a commonly used inotropic agent in patients with cardiovascular decompensation which is caused by depressed contractility secondary to organic heart disease, cardiac surgery, cardiac arrest or acute myocardial infarction. Dobutamine-associated adverse effects are mainly due to sympathetic overstimulation causing chest discomfort, palpitations, tremors, headache, shortness of breath, hypertension, nausea, vomiting and eosinophilic myocarditis. Myoclonus is a neurological side effect that may be rarely caused by dobutamine infusion, especially among patients with chronic kidney disease (CKD). We are reporting a rare case of dobutamine-induced multifocal myoclonus in a patient with CKD during the management of decompensated heart failure.

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Source
http://dx.doi.org/10.1136/bcr-2024-262214DOI Listing

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