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Malakoplakia Associated with Diarrhoea and Colonic Lesions After Rituximab Treatment.
Eur J Case Rep Intern Med
December 2024
Gastroenterology Department, Adan Hospital Kuwait, Hadiya, Kuwait.
Unlabelled: Malakoplakia is a rare granulomatous condition that occurs due to defective lysosomal digestion during phagocytosis and can mimic inflammatory bowel disease (IBD) or malignancies, particularly in immunosuppressed patients. We report the case of a 62-year-old male with IgG4-related orbitopathy, who developed persistent diarrhoea and colonic lesions 6 weeks after receiving rituximab therapy for nephrotic syndrome secondary to membranoproliferative glomerulonephritis. Colonoscopy revealed pancolitis with mucosal granularity, loss of vascular pattern, and small nodules, raising initial suspicion for IBD.
View Article and Find Full Text PDFIgG4-related Gastrointestinal Disease Diagnosed by Underwater Endoscopic Mucosal Resection.
Clin Gastroenterol Hepatol
December 2024
Department of Surgical Pathology, Sendai Kousei Hospital, Miyagi, Japan.
IgG4 in the gut: Gastrointestinal IgG4-related disease or a new subtype of inflammatory bowel disease.
Autoimmun Rev
December 2024
Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy. Electronic address:
IgG4-related disease (IgG4-RD) is a chronic inflammatory condition characterized by tissue infiltration with IgG4-positive plasma cells, leading to fibrosis and organ dysfunction. While primarily affecting the pancreas, bile ducts, and salivary glands, IgG4-RD can also involve the gastrointestinal tract, raising questions about its relationship with inflammatory bowel disease (IBD). Recent studies suggest that patients with IBD may exhibit histological and serological features consistent with IgG4-RD, such as a dense lymphoplasmacytic infiltration, a storiform-type of fibrosis and a prominent IgG4 immune response.
View Article and Find Full Text PDFMultisystem diseases in the abdomen and pelvis: imaging manifestations and diagnostic roles of cross-sectional imaging.
Abdom Radiol (NY)
October 2024
Department of Radiology, Konkuk University Medical Center, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
Systemic diseases, such as IgG4-related disease, sarcoidosis, and amyloidosis, usually involve multiple systems or organs simultaneously or sequentially. The gastrointestinal tract, hepatobiliary system, and genitourinary tract are commonly involved in many multisystem diseases and can also be the first sites with disease involvement. Cross-sectional imaging, such as CT and MR, plays an important role in the diagnosis and management of multisystem diseases by aiding in the evaluation of multiorgan involvement.
View Article and Find Full Text PDFImmunoglobulin G4-related disease in an elderly patient with treatment-resistant headache: a case report.
Encephalitis
October 2024
Department of Neurology, Istanbul Bakirköy Mazhar Osman Mental Health and Neurological Diseases Education and Research Hospital, Health Sciences University, Istanbul, Turkiye.
Article Synopsis
- IgG4-related disease is an immune disorder mainly seen in older men that affects multiple organ systems, often causing symptoms like headaches and gastrointestinal issues.
- A case study details a 78-year-old woman whose persistent headaches and diarrhea led to a diagnosis of IgG4-related disease, confirmed by imaging and biopsy.
- After initial treatments failed, switching to rituximab helped resolve her headaches and control diarrhea, emphasizing the need to consider IgG4-related disease in similar cases of unexplained symptoms in elderly patients.
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