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Chia Oil ( L.) Improves the Intestinal Health of Rats Fed a Hypercaloric Diet. | LitMetric

AI Article Synopsis

  • - Chia oil, known for its beneficial fatty acids, was studied for its potential to enhance intestinal health in rats consuming a high-fat and high-fructose diet.
  • - The research involved two main phases: initially, the rats were placed on either a standard diet or a HFHF diet, followed by a chia oil treatment for the HFHF group.
  • - Results showed that chia oil increased beneficial compounds and structures in the gut, indicating a positive impact on gut health, although it didn't significantly change the overall diversity of gut bacteria.

Article Abstract

Background: A diet rich in fat and sugar is present in society everyday life, leading to the development of metabolic changes, especially in intestinal microbiota. Chia oil is a source of alpha-linolenic acid, which has antioxidant and anti-glycemic effects. Based on this, we hypothesized that chia oil may promote intestinal health.

Objective: The study aims to investigate the effects of chia oil on gut microbiota and intestinal health in rats fed a high-fat and high-fructose diet (HFHF).

Methods: The animals were separated into two groups and received the following diets: standard murine diet (AIN-93M) ( = 10) and HFHF ( = 20) to induce metabolic changes (phase I) during eight weeks. After that, the AIN-93M group remained unchanged, while the HFHF group was divided into two groups: HFHF ( = 10) and HFHF with chia oil (HFHF+CO) ( = 10) for ten weeks (phase II, chia oil treatment). We analyzed immunoglobulin A (IgA) levels, cecal pH, short-chain fatty acids (SCFAs), intestinal permeability, intestinal microbiome composition, histomorphometry, and murinometric parameters.

Results: Chia oil consumption increased alpha-linolenic acid intake, IgA levels, propionic acid production, cecum weight, goblet cell number, thickness and depth of intestinal crypts, and the thickness of both circular and longitudinal muscle layers of the colon, and decreased cecal pH. No change was observed in the alpha and beta diversity between the HFHF and HFHF+CO groups. The HFHF+CO diet increased the relative abundance of genera sp., sp., and sp., compared to the AIN-93M group. No difference was observed in the intestinal permeability among the groups.

Conclusion: Chia oil consumption is an alternative for improving the intestinal health of rats fed a HFHF diet.

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Source
http://dx.doi.org/10.1080/27697061.2024.2431271DOI Listing

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