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First-in-human SPECT/CT imaging of [At]PSMA-5: targeted alpha therapy in a patient with refractory prostate cancer.
Eur J Nucl Med Mol Imaging
December 2024
Department of Radiology, Graduate School of Medicine, Osaka University, Suita, Japan.
First-in-human study of Tc-labeled fucoidan, a SPECT tracer targeting P-selectin.
EJNMMI Res
November 2024
Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- The study focuses on Tc-fucoidan, a compound derived from brown algae, which targets P-selectin for early identification of thrombosis.
- In the safety assessment involving ten healthy volunteers, Tc-fucoidan was well tolerated with no adverse effects and demonstrated reliable uptake in human thrombi in gamma counting experiments.
- Although the results showed potential for imaging thrombi in certain cases, the overall findings do not support further clinical use of Tc-fucoidan for diagnosing deep vein thrombosis (DVT), suggesting exploration of alternative P-selectin tracers instead.
Safety and Feasibility of Interventional Hybrid Fluoroscopy and Nuclear Imaging in the Work-up Procedure of Hepatic Radioembolization.
Radiol Imaging Cancer
November 2024
From the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.
Purpose To evaluate the safety and feasibility of a novel hybrid nuclear and fluoroscopy C-arm scanner to be used during the work-up procedure of hepatic radioembolization. Materials and Methods In this prospective first-in-human clinical study, 12 participants (median age, 67 years [range: 37-78 years]; nine [75%] male, three [25%] female) with liver tumors undergoing work-up for yttrium 90 radioembolization were included (ClinicalTrials.gov NCT06013774).
View Article and Find Full Text PDFFirst-in-human infection imaging with Zr-labelled leukocytes and comparison of scan quality with [Tc]Tc-HMPAO-labelled leukocytes.
Front Nucl Med
July 2024
Nuclear Medicine Research Infrastructure (NuMeRI) and Department of Nuclear Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Article Synopsis
- Nuclear medicine infection imaging typically uses technetium-99m radiolabelled leukocytes with SPECT, but zirconium-89 offers improved sensitivity and image quality through PET technology, allowing delayed imaging for better accuracy in locating infections.
- A study explored the application of zirconium-labelled leukocytes for infection imaging in patients, comparing results from PET and SPECT to assess the quality and distribution of these radiolabelled cells.
- Results showed successful labelling with high efficiency and viability of the zirconium-labelled leukocytes, indicating potential benefits over traditional imaging methods.
Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [Tc]Tc(CO)-(HE)-Ec1 for Visualization of EpCAM-Expressing Lung Cancer.
Cancers (Basel)
August 2024
Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden.
A high level of EpCAM overexpression in lung cancer makes this protein a promising target for targeted therapy. Radionuclide visualization of EpCAM expression would facilitate the selection of patients potentially benefiting from such treatment. Single-photon computed tomography (SPECT) using Tc-labeled engineered scaffold protein DARPin Ec1 has shown its effectiveness in imaging tumors with overexpression of EpCAM in preclinical studies, providing high contrast just a few hours after injection.
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