AI Article Synopsis
- A study was conducted to assess the accuracy of the FreeStyle Libre 2 (FSL2), a glucose monitoring device, in rabbits since it had been validated in other animal species but not in rabbits.
- Six healthy rabbits were monitored for interstitial glucose (IG) and blood glucose (BG) levels under various conditions, including before and after administering insulin.
- The FSL2 showed limited accuracy compared to a standard blood glucose meter, especially in the euglycaemic range, but it was still able to effectively identify hypoglycaemic states in the rabbits.
Article Abstract
Background: Studies are currently being conducted on rabbits requiring serial glucose monitoring. The FreeStyle Libre 2 (FSL2), a serial glucose monitoring device, has been validated in humans, dogs and cats, but not in rabbits.
Objectives: This study aimed to evaluate the accuracy of the FSL2 in rabbits.
Methods: Six healthy rabbits were used in this study. Interstitial glucose (IG) was measured using the FSL2, and blood glucose (BG) was measured using a portable blood glucose meter (PBGM); their results were compared with those from a clinical chemistry analyser. For the first 3 h, IG and BG were measured at 1-h intervals. Subsequently, they were measured every 8 h over a 48-h period. Regular insulin 0.2 U/kg was then administered to the rabbits, and IG and BG were measured every 15 min over a 90-min period.
Results: Before insulin treatment, no measurements fell within the hypoglycaemic range (BG < 100 mg/dL). In the euglycaemic range (BG ≥ 100 mg/dL), the PBGM and FSL2 showed 85.7% and 23.8% accuracies, respectively. After insulin treatment, the PBGM showed 95.5% and 81.3% accuracies in the hypoglycaemic and euglycaemic ranges, respectively. The FSL2 showed 68.1% and 37.5% accuracies in the hypoglycaemic and euglycaemic ranges, respectively. Parkes consensus error grid analysis showed that the PBGM and FSL2 had 100% agreement for Zones A (no effect on clinical action) and B (altered clinical action unlikely to affect outcome) in rabbits with and without insulin treatment.
Conclusions: There was limited agreement between the FSL2 and reference standard BG measurements. However, the FSL2 allows clinically acceptable identification of hypoglycaemic states in rabbits.
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|---|---|
| http://dx.doi.org/10.1002/vms3.70166 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651090 | PMC |
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