Background: Lamotrigine, an antiseizure medication used for epilepsy and bipolar disorders, is often prescribed to women of childbearing age due to relatively low teratogenic risk. It is known that lamotrigine use in lactation leads to detectable concentrations in breast milk, although concentrations vary significantly among individuals.
Case Presentation: A 35-year-old pregnant woman with epilepsy presented to our outpatient clinic. She was seizure-free and was taking lamotrigine 200 mg once daily. She is highly motivated to breastfeed her baby after birth but is concerned about the infant's exposure to lamotrigine through lactation. Lamotrigine concentrations were measured in both the breast milk and plasma of the suckling infants.
Conclusions: Although lamotrigine is excreted into breast milk, and detectable in infants, the benefits of breastfeeding should not be overlooked. Higher plasma concentrations generally lead to higher breast milk concentrations, so aiming for the lowest possible maternal plasma levels is beneficial. These findings underscore the importance of TDM in this population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/FTD.0000000000001299 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Employee Management in Dairy Farms Associated with Bulk Tank Somatic Cell Count and New Mastitis Infection Risk.
Vet Sci
December 2024
Department of Veterinary and Animal Sciences, Section for Production, Nutrition and Health, University of Copenhagen, 1870 Frederiksberg C, Denmark.
For decades, bovine mastitis and milk quality have been a focus area for research, agricultural extension, and dairy processors worldwide, yet employee management as a factor in udder health management has received limited attention. This is mainly because the focus has previously been on more classical areas covered by the National Mastitis Council Mastitis Control Program (NMC 10-point plan) in English-speaking countries. Therefore, we wanted more background information on employee management on dairy farms, to identify the human factor of udder health management.
View Article and Find Full Text PDFAbrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4 T-Cells While Decreasing Protein Synthesis in Kidney Cells.
Curr Issues Mol Biol
December 2024
Foodborne Toxin Detection and Prevention Research Unit, Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA.
Abrin, a toxin of the rosary pea plant (), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown. Certain superantigen microbial toxins such as Staphylococcus enterotoxin type A, type D, type E or streptococcal pyrogenic exotoxin type C also lead to various diseases including autoimmune disorders of the nervous system. Here, the effect of abrin toxin on the immune reaction was studied in human CD4 T-cell lines, and its inhibition of protein synthesis in kidney cells.
View Article and Find Full Text PDFBreastfeeding and infant gut microbiota: influence of bioactive components.
Gut Microbes
December 2025
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Establishment of the gut microbiota during infancy is critical for host health with long-lasting implications. In this orchestrated process, microbial assembly is influenced by an increasing number of genetic and environmental factors, among which breastfeeding is considered as one of the most significant drivers for infant gut microbiota development. As the optimal diet for the infants, maternal milk provides numerous nutritional, microbial, and bioactive components to ensure the most adequate microbial growth and development of a 'healthy' gut microbiota during early life.
View Article and Find Full Text PDFHuman milk microbiota and oligosaccharides in colostrum and mature milk: comparison and correlation.
Front Nutr
December 2024
Department of Clinical Laboratory, Dalian Women and Children's Medical Group, Dalian, China.
Background: The interaction between the human breast milk microbiota and human milk oligosaccharides (HMOs) plays a crucial role in the healthy growth and development of infants. We aimed to clarify the link between the breast milk microbiota and HMOs at two stages of lactation.
Methods: The microbiota and HMOs of 20 colostrum samples (C group, 1-5 days postpartum) and 20 mature milk samples (S group, 42 days postpartum) collected from postpartum mothers were analyzed using 16S rRNA gene high-throughput sequencing and high-performance liquid chromatography-tandem mass spectrometry.
Proactive Management of Lactation in the Birth Hospital to Ensure Long-Term Milk Production and Sustainable Breastfeeding.
J Midwifery Womens Health
December 2024
Midwifery Practice at Tampa General Hospital, Tampa, Florida.
Individuals who are at risk of not achieving a full milk supply are often overlooked in scientific literature. There is available guidance to help establish an adequate milk supply for healthy individuals experiencing a physiologic labor and birth, and there are robust recommendations for the lactating parents of small, sick, and preterm newborns to ensure that these newborns can receive human milk. Missing from the literature are clinical practice guidelines that address the preexisting health, pregnancy, birth, or newborn-related risk factors for suboptimal lactation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!